Dbh - dopamine beta-hydroxylase Gene

中文名称：多巴胺 β-羟化酶

种属: Rattus norvegicus

同用名: DOPBHY

关于 Dbh

功能概要

该基因编码的蛋白可启动铜离子结合活性和多巴胺 β-单加氧酶活性。参与多个过程，包括细胞生物胺代谢过程；细胞对锰离子的反应；和细胞对尼古丁的反应。位于多个细胞成分中，包括轴突；树突;和神经细胞体。脑缺血的生物标志物；高血压;精神抑郁症；和门静脉高压症。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；注意力缺陷多动障碍;多巴胺β-羟化酶缺乏症；高血压;和有先兆的偏头痛。与人类 DBH（多巴胺 β-羟化酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular biogenic amine metabolic process; cellular response to manganese ion; and cellular response to nicotine. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]