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  2. QPCT - glutaminyl-peptide cyclotransferase Gene

QPCT - glutaminyl-peptide cyclotransferase Gene

中文名称:谷氨酰胺酰肽环转移酶

种属: Homo sapiens

同用名: QC; GCT; sQC

基因 ID: 25797 | 基因类型: protein coding

关于 QPCT

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,344,630-37,373,322 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues.

功能概要

该基因编码人垂体谷氨酰胺酰环化酶,它负责许多神经内分泌肽中焦谷氨酰残基的存在。该酶的氨基酸序列与牛谷氨酰胺酰环化酶的氨基酸序列有 86% 的同一性。[RefSeq 提供,2008 年 7 月]

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine Peptides. The amino acid sequence of this Enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

QPCT 基因产物(1)

mRNA Protein Name
NM_012413.4 NP_036545.1 glutaminyl-peptide cyclotransferase precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutaminyl-peptide cyclotransferase activity IDA
IDA: 通过直接分析推断
21288892 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
21288892 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
IDA: 通过直接分析推断
21288892 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

QPCT 蛋白结构

Peptidase_M28

Peptidase_M28: Peptidase family M28 (134 - 344)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
蛋白主名 其他名称

glutaminyl-peptide cyclotransferase

EC

重组 QPCT 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76560 QPCT Protein, Human (sf9, His) Q16769-1 (A33-L361) ≥95%

关联疾病

疾病名称 别名
Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British

Fbd

Presenile Dementia With Spastic Ataxia

Familial British Dementia

Abri Amyloidosis

Cerebral Amyloid Angiopathy, British Type

Itm2b-Related Cerebral Amyloid Angiopathy 1

Familial Dementia, British Type

Cerebral Amyloid Angiopathy, Itm2b-Related 1

CAA-ITM2B1

Cerebral Amyloid Angiopathy British Type

Dementia, Familial, British

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus QPCT VGNC VGNC:33598
Mus musculus QPCT MGD MGI:1917786
Macaca mulatta QPCT VGNC VGNC:76636
Felis catus QPCT VGNC VGNC:69199
Rattus norvegicus QPCT RGD RGD:1562284
Canis familiaris QPCT VGNC VGNC:45233
Others QPCT NCBI