1. Gene
  2. ZNF451 - zinc finger protein 451 Gene

ZNF451 - zinc finger protein 451 Gene

中文名称:锌指蛋白 451

种属: Homo sapiens

同用名: ZATT; COASTER; dJ417I1.1

基因 ID: 26036 | 基因类型: protein coding

关于 ZNF451

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:57,090,188-57,170,305 (from NCBI)

This gene has 18 transcripts (splice variants), 131 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues.

功能概要

启用 SUMO 连接酶活性和转录辅阻遏物活性。参与氮化合物代谢过程的负调控;转化生长因子β受体信号通路的负调控;和蛋白质苏木化。位于核内。 [由基因组资源联盟提供,2022 年 4 月]

Enables SUMO Ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF451 基因产物(3)

mRNA Protein Name
NM_001031623.3 NP_001026794.1 E3 SUMO-protein ligase ZNF451 isoform 1
NM_001257273.2 NP_001244202.1 E3 SUMO-protein ligase ZNF451 isoform 3
NM_015555.3 NP_056370.2 E3 SUMO-protein ligase ZNF451 isoform 2

ZNF451 蛋白结构

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (253 - 272)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (606 - 625)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (753 - 776)

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  • 1061 a.a.
蛋白主名 其他名称

E3 SUMO-protein ligase ZNF451

E3 SUMO-protein transferase ZNF451

ZNF451 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF451 Q9Y4E5 UBE2I Homo sapiens P63279
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZNF451 MGD MGI:2137896
Rattus norvegicus ZNF451 RGD RGD:1305865
Macaca mulatta ZNF451 VGNC VGNC:79308
Felis catus ZNF451 VGNC VGNC:108381
Bos taurus ZNF451 VGNC VGNC:37279
Canis familiaris ZNF451 VGNC VGNC:48732