1. Gene
  2. Scn11a - sodium voltage-gated channel alpha subunit 11 Gene

Scn11a - sodium voltage-gated channel alpha subunit 11 Gene

中文名称:钠电压门控通道 α 亚基 11

种属: Rattus norvegicus

同用名: NaN

基因 ID: 29701 | 基因类型: protein coding

关于 Scn11a

Primary_assembly 8: 119,496,769-119,567,044 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 96 orthologues, 26 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 4.9), Spleen (RPKM 4.2) and 3 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动电压门控钠通道活动。预计参与多个过程,包括神经元动作电位;调节疼痛的感官知觉;和钠离子跨膜转运。预计在钠离子传输的上游或内部起作用。位于轴突。在谷氨酸能突触中活跃。是突触前膜的组成部分。该基因的人类直向同源物与家族性发作性疼痛综合征 3 和遗传性感觉和自主神经病 7 型有关。与人类 SCN11A(钠电压门控通道 α 亚基 11)直向同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable voltage-gated Sodium Channel activity. Predicted to be involved in several processes, including neuronal action potential; regulation of sensory perception of pain; and sodium ion transmembrane transport. Predicted to act upstream of or within sodium ion transport. Located in axon. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 3 and hereditary sensory and autonomic neuropathy type 7. Orthologous to human SCN11A (sodium voltage-gated channel alpha subunit 11). [provided by Alliance of Genome Resources, Apr 2022]

Scn11a 基因产物(1)

mRNA Protein Name
NM_019265.2 NP_062138.1 sodium channel protein type 11 subunit alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11376006 RGD
enables voltage-gated sodium channel activity IDA
IDA: 通过直接分析推断
10196578 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in membrane depolarization during action potential IDA
IDA: 通过直接分析推断
10196578 RGD
involved in optic nerve development IEP
IEP: 通过表达模式推断
22473424 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
21118538 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
19162133 RGD
is active in plasma membrane IDA
IDA: 通过直接分析推断
10196578 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
19162133 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Scn11a 蛋白结构

Ion_trans

Ion_trans: pfam00520 (127 - 403)

Ion_trans

Ion_trans: pfam00520 (570 - 806)

Na_trans_assoc

Na_trans_assoc: pfam06512 (810 - 1028)

Ion_trans

Ion_trans: pfam00520 (1032 - 1296)

Na_channel_gate

Na_channel_gate: cd13433 (1288 - 1340)

Ion_trans

Ion_trans: pfam00520 (1344 - 1594)

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  • 1765 a.a.
蛋白主名 其他名称

sodium channel protein type 11 subunit alpha

sensory neuron sodium channel 2

sodium channel protein type XI subunit alpha

sodium channel, voltage-gated, type 11, alpha polypeptide

sodium channel, voltage-gated, type XI, alpha polypeptide

sodium channel, voltage-gated, type XI, alpha subunit

sodium channel, voltage-gated, type11, alpha polypeptide

voltage-gated sodium channel NAV1.9b

voltage-gated sodium channel subunit alpha Nav1.9

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn11a NCBI NCBI:11280