1. Gene
  2. Ccr6 - C-C motif chemokine receptor 6 Gene

Ccr6 - C-C motif chemokine receptor 6 Gene

中文名称:CC 基序趋化因子受体 6

种属: Rattus norvegicus

基因 ID: 308163 | 基因类型: protein coding

关于 Ccr6

Primary_assembly 1: 52,474,168-52,498,603 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 299 orthologues, 24 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 8.7), Thymus (RPKM 21.) and 1 other tissue.

功能概要

预测该基因编码的蛋白可启动 CC 趋化因子结合活性和 CC 趋化因子受体活性。参与细胞溶质钙离子浓度的正向调节;树突状细胞趋化性的正调节;和上皮细胞迁移的正调节。预测位于细胞表面;精子鞭毛;和精子质膜。预计在质膜外侧活跃。膜增生性肾小球肾炎和短暂性脑缺血的生物标志物。与人 CCR6(CC 基序趋化因子受体 6)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in positive regulation of cytosolic calcium ion concentration; positive regulation of dendritic cell chemotaxis; and positive regulation of epithelial cell migration. Predicted to be located in cell surface; sperm flagellum; and sperm plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of membranoproliferative glomerulonephritis and transient cerebral ischemia. Orthologous to human CCR6 (C-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Ccr6 基因产物(1)

mRNA Protein Name
NM_001013145.1 NP_001013163.1 C-C chemokine receptor type 6
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
19233848 RGD
involved in positive regulation of dendritic cell chemotaxis IMP
IMP: 通过突变表型推断
14673014 RGD
involved in positive regulation of epithelial cell migration IDA
IDA: 通过直接分析推断
19233848 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ccr6 蛋白结构

7tmA_CCR6

7tmA_CCR6: cd15172 (37 - 64)

7tmA_CCR6

7tmA_CCR6: cd15172 (37 - 317)

7tmA_CCR6

7tmA_CCR6: cd15172 (71 - 96)

7tmA_CCR6

7tmA_CCR6: cd15172 (108 - 138)

7tmA_CCR6

7tmA_CCR6: cd15172 (152 - 174)

7tmA_CCR6

7tmA_CCR6: cd15172 (201 - 230)

7tmA_CCR6

7tmA_CCR6: cd15172 (237 - 267)

7tmA_CCR6

7tmA_CCR6: cd15172 (285 - 310)

  • 0
  • 100
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  • 300
  • 366 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 6

CC chemokine receptor 6

chemokine (C-C motif) receptor 6

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr6 NCBI NCBI:1235