NRG1 - neuregulin 1 Gene

种属: Homo sapiens (human)

同用名: GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2

基因 ID: 3084 | 基因类型: protein coding

关于 NRG1

功能概要

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as Cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

NRG1 基因产物(1)

mRNA	Protein	Name
XM_054360388.1	XP_054216363.1	pro-neuregulin-1, membrane-bound isoform isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ErbB-3 class receptor binding	IDA IDA: 通过直接分析推断	7556068	GOA
enables ErbB-3 class receptor binding	IPI IPI: 通过物理相互作用推断	11389077	GOA
enables growth factor activity	IDA IDA: 通过直接分析推断	11389077	GOA
enables integrin binding	IDA IDA: 通过直接分析推断	20682778	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7592681	GOA
enables protein tyrosine kinase activator activity	IDA IDA: 通过直接分析推断	7556068	GOA
enables receptor ligand activity	IDA IDA: 通过直接分析推断	8702723	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	7514177	GOA
enables transcription coregulator activity	IDA IDA: 通过直接分析推断	15073182	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERBB signaling pathway	IDA IDA: 通过直接分析推断	11389077	GOA
involved in ERBB signaling pathway	IMP IMP: 通过突变表型推断	20682778	GOA
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: 通过直接分析推断	8702723	GOA
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: 通过直接分析推断	19632177	GOA
involved in ERBB3 signaling pathway	IDA IDA: 通过直接分析推断	27353365	GOA
involved in ERBB4 signaling pathway	IDA IDA: 通过直接分析推断	15219672	GOA
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: 通过直接分析推断	8702723	GOA
involved in activation of protein kinase B activity	IMP IMP: 通过突变表型推断	20682778	GOA
involved in activation of transmembrane receptor protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	9553078	GOA
involved in cardiac muscle cell myoblast differentiation	IDA IDA: 通过直接分析推断	17336907	GOA
involved in cell population proliferation	IDA IDA: 通过直接分析推断	11389077	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: 通过直接分析推断	7514177	GOA
involved in endocardial cell differentiation	IDA IDA: 通过直接分析推断	17336907	GOA
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15073182	GOA
involved in negative regulation of cardiac muscle cell apoptotic process	IDA IDA: 通过直接分析推断	9553078	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: 通过直接分析推断	9553078	GOA
involved in negative regulation of secretion	IDA IDA: 通过直接分析推断	10559227	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	20682778	GOA
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: 通过直接分析推断	9553078	GOA
involved in positive regulation of cell adhesion	IDA IDA: 通过直接分析推断	7556068	GOA
involved in positive regulation of cell growth	IDA IDA: 通过直接分析推断	9553078	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	20682778	GOA
involved in positive regulation of peptidyl-tyrosine autophosphorylation	IDA IDA: 通过直接分析推断	15219672	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: 通过直接分析推断	10559227	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: 通过直接分析推断	16221846	GOA
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: 通过突变表型推断	16221846	GOA
involved in sequestering of metal ion	EXP EXP: 通过实验结果推断	25944317	GOA
involved in ventricular cardiac muscle cell differentiation	IDA IDA: 通过直接分析推断	9553078	GOA
involved in ventricular trabecula myocardium morphogenesis	IDA IDA: 通过直接分析推断	17336907	GOA
involved in wound healing	IDA IDA: 通过直接分析推断	12646923	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	12646923	GOA
is active in extracellular space	IDA IDA: 通过直接分析推断	8702723	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	11389077	GOA
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	16221846	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	16221846	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

pro-neuregulin-1, membrane-bound isoform

NRG1 class VII isoform alpha 2a	NRG1 class VII isoform alpha 2b
NRG1 class VII isoform alpha beta 2a	NRG1 class VII isoform alpha beta 3
NRG1 class VII isoform beta 2a	NRG1 class VII isoform beta 3
acetylcholine receptor-inducing activity	glial gro

重组 NRG1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7365	NRG1-beta 1 Protein, Human	Q02297-6 (S177-E241)	≥95%
HY-P70524	NRG1-beta 1 Protein, Human (245a.a)	Q02297-6/AAA58639.1 (S2-K246)	≥95%
HY-P70967	NRG1-beta 1 Protein, Human (246a.a, His)	AAA58639.1 (M1-K246)	≥95%
HY-P72007	NRG1-beta 1 Protein, Human (65a.a, His)	Q02297-6 (S177-E241)	≥95%
HY-P73304	NRG1-beta 2 Protein, Human	Q02297-7 (S177-Q237)/E5RIG8 (S23-Q83)	≥95%
HY-P73325	NRG1-alpha Protein, Human (222a.a, HEK293, Fc)	Q02297-1 (S20-K241)	≥95%
HY-P73326	NRG1-alpha Protein, Human (HEK293, His)	Q02297-1 (S20-K241)	≥95%
HY-P73328	NRG1-beta 1 Protein, Human (HEK293)	Q02297-6 (S2-K246)	≥95%
HY-P73329	NRG1-beta 1 Protein, Human (245a.a, HEK293, Fc)	Q02297-6 (S2-K246)	≥95%
HY-P73330	NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc)	Q02297-6 (T176-K246)	≥95%
HY-P73327	NRG1-alpha Protein, Human (65a.a, HEK293, Fc)	Q02297-1 (S177-K241)	≥95%
HY-P73744	NRG1-beta 2 Protein, Human (HEK293, His)	Q02297-7/NP_001153480 (S20-K238)	≥95%
HY-P73745	NRG1-beta 2 Protein, Human (HEK293, Fc)	NP_001153480 (S177-Q237)	≥95%
HY-P71171A	NRG1-beta 1 Protein, Human (CHO)	Q02297-6 (T176-K246)	≥95%
HY-P700427	NRG1-beta 1 Protein, Human (HEK293, His)	Q02297-6 (S20-R247)	≥95%

目录号	产品名	作用方式	纯度	Phase
HY-P99268	Seribantumab		≥95.0%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-168060	(8R)-8-Hydroxyepoxyboetirane A	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NRG1	NCBI
Mus musculus	NRG1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NRG1 - neuregulin 1 Gene

关于 NRG1

功能概要

NRG1 基因产物(1)

重组 NRG1 蛋白

直系同源

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NRG1 - neuregulin 1 Gene

关于 NRG1

功能概要

NRG1 基因产物(1)

重组 NRG1 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z