2. 重组蛋白
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins
  6. Neuregulin-1 (NRG1)
  7. NRG1-beta 1 蛋白, Human (71a.a, HEK293, Fc)

NRG1-beta 1 蛋白, Human (71a.a, HEK293, Fc)

目录号: HY-P73330
产品使用指南

HRG1-β1 是结构相关的多肽生长因子家族，来源于选择性剪接基因，诱导 Fn14 在 MCF7 细胞中表达。NRG1-beta 1 蛋白, Human (71a.a, HEK293, Fc) 是重组的 NRG1-β 1 蛋白，由 HEK293 表达，带有 N-hFc 标签。NRG1-beta 1 蛋白, Human (71a.a, HEK293, Fc) 全长 71 个氨基酸，分子量约为 ~38 kDa。

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描述

HRG1-β1 belongs to a family of structurally-related polypeptide growth factors derived from alternatively spliced genes, induces Fn14 expression in MCF7 cells. NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is the recombinant human-derived NRG1-beta 1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) is 71 a.a., with molecular weight of ~38 kDa.
研究背景

HRG1-β1 能够激活亲本 MCF7 细胞中的 HER2/HER3 信号传导并上调 Fn14 基因表达。MCF7/HER2-18 细胞中 HRG1-β1 介导的 Fn14 上调是最大程度产生 MMP-9 所必需的。
种属

Human
表达系统

HEK293
标签

N-hFc
蛋白编号

Q02297-6 (T176-K246)
基因 ID
蛋白结构
N-term
hFc
NRG1-beta 1 (T176-K246)
Accession # Q02297-6
C-term
同用名
Pro-neuregulin-1; Neuregulin-1; ARIA; HRG; NRG1; GGF; HGL; HRGA; NDF; SMDF
分子量

Approximately 38 kDa
纯度

Greater than 86% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

NRG1-beta 1 Protein, Human (71a.a, HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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