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  3. Rorb - RAR-related orphan receptor B Gene

Rorb - RAR-related orphan receptor B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAR 相关孤儿受体 B

种属: Rattus norvegicus

基因 ID: 309288 | 基因类型: protein coding

关于 Rorb

Primary_assembly 1: 216,363,629-216,544,390 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 398 orthologues, 19 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 5.4), Uterus (RPKM 19.7) and 1 other tissue.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它是一种 DNA 结合蛋白，可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已被证明与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，并有助于调节一些与昼夜节律有关的基因的表达。 [RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Rorb 基因产物(2)

mRNA Protein Name
NM_001270958.1 NP_001257887.1 nuclear receptor ROR-beta
NM_001270958.1 NP_001257887.1 nuclear receptor ROR-beta
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7961794 RGD
enables melatonin receptor activity IDA
IDA: 通过直接分析推断
7961794 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to retinoic acid IDA
IDA: 通过直接分析推断
12958591 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
15781226 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9729429 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9729429 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
17067745 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rorb 蛋白结构

NR_DBD_ROR

NR_DBD_ROR: cd06968 (2 - 96)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (209 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
蛋白主名 其他名称

nuclear receptor ROR-beta

RAR-related orphan receptor beta

nuclear receptor RZR-beta

nuclear receptor subfamily 1 group F member 2

retinoid-related orphan receptor-beta

transcription factor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12129 RORB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12130 Rorb Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12131 Rorb Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rorb NCBI NCBI:6096
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