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  2. Tiparp - TCDD-inducible poly(ADP-ribose) polymerase Gene

Tiparp - TCDD-inducible poly(ADP-ribose) polymerase Gene

中文名称:TCDD 诱导聚 (ADP-核糖) 聚合酶

种属: Rattus norvegicus

同用名: RM1

基因 ID: 310467 | 基因类型: protein coding

关于 Tiparp

Primary_assembly 2: 149,753,682-149,780,327 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 208 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in Heart (RPKM 15.5), Lung (RPKM 117.2) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动 NAD+ ADP-核糖基转移酶活性;顺式调控区序列特异性 DNA 结合活性;和蛋白质 ADP-核糖基酶活性。参与对 2,3,7,8-四氯二苯并二恶英的反应。预测位于核内。与人类 TIPARP(TCDD 诱导型聚(ADP-核糖)聚合酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable NAD+ ADP-ribosyltransferase activity; cis-regulatory region sequence-specific DNA binding activity; and protein ADP-ribosylase activity. Involved in response to 2,3,7,8-tetrachlorodibenzodioxine. Predicted to be located in nucleus. Orthologous to human TIPARP (TCDD inducible poly(ADP-ribose) polymerase). [provided by Alliance of Genome Resources, Apr 2022]

Tiparp 基因产物(2)

mRNA Protein Name
NM_001107679.3 NP_001101149.2 protein mono-ADP-ribosyltransferase TIPARP
NM_001107679.3 NP_001101149.2 protein mono-ADP-ribosyltransferase TIPARP
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
IEP: 通过表达模式推断
24355419 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Tiparp 蛋白结构

WWE

WWE: pfam02825 (347 - 400)

TCCD_inducible_PARP_like

TCCD_inducible_PARP_like: cd01439 (528 - 647)

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  • 657 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase TIPARP

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tiparp NCBI NCBI:25976