Porcn - porcupine O-acyltransferase Gene

中文名称：豪猪 O-酰基转移酶

种属: Rattus norvegicus

同用名: RGD1564947

关于 Porcn

功能概要

预测该基因编码的蛋白具有 Wnt 蛋白结合活性和棕榈油酰转移酶活性。预计参与多个过程，包括Wnt蛋白分泌；蛋白质脂化；和突触后膜神经递质受体水平的调节。预测作用于糖蛋白代谢过程的上游或内部。预计是内质网膜的组成部分。预计是 AMPA 谷氨酸受体复合物的一部分。预计在内质网中有活性；谷氨酸能突触；和膜。该基因的人类直系同源物与局灶性真皮发育不全有关。与人类 PORCN（豪猪 O-酰基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Predicted to be involved in several processes, including Wnt protein secretion; protein lipidation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to act upstream of or within glycoprotein metabolic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum; glutamatergic synapse; and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (Porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]