Dot1l - DOT1 like histone lysine methyltransferase Gene

中文名称：DOT1 样组蛋白赖氨酸甲基转移酶

种属: Rattus norvegicus

关于 Dot1l

功能概要

预测该基因编码的蛋白可启动组蛋白甲基转移酶活性（H3-K79 特异性）。预计参与多个过程，包括 DNA 损伤检查点信号；通过 JAK-STAT 调节受体信号通路；和亚端粒异染色质组装。预计在上游或内部对基因表达产生负面影响。预计作用于组蛋白 H3-K79 甲基化的上游或内部；细胞群增殖的正向调节；和 RNA 聚合酶 II 对转录的正调控。预测位于细胞质和核质中。预计是含蛋白质复合物的一部分。预计活跃于核心。该基因的人类直系同源物与混合表型急性白血病有关。与人 DOT1L 同源（DOT1 像组蛋白赖氨酸甲基转移酶）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Histone Methyltransferase activity (H3-K79 specific). Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin assembly. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within histone H3-K79 methylation; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]