2. Gene
  3. DOT1L - DOT1 like histone lysine methyltransferase Gene

DOT1L - DOT1 like histone lysine methyltransferase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DOT1 样组蛋白赖氨酸甲基转移酶

种属: Homo sapiens

同用名: DOT1; KMT4

基因 ID: 84444 | 基因类型: protein coding

关于 DOT1L

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,163,933-2,232,578 (from NCBI)

This gene has 9 transcripts (splice variants) and 205 orthologues. Broad expression in testis (RPKM 18.3), bone marrow (RPKM 5.1) and 22 other tissues.

功能概要

该基因编码的蛋白质是一种组蛋白甲基转移酶，可使组蛋白 H3 的赖氨酸 79 甲基化。它对游离核心组蛋白无活性，但对核小体显示出显着的组蛋白甲基转移酶活性。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene is a Histone Methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant Histone Methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

DOT1L 基因产物(8)

mRNA Protein Name
NM_032482.3 NP_115871.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform 1
XM_011528361.3 XP_011526663.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X6
NM_001411141.1 NP_001398070.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform 2
XM_047439515.1 XP_047295471.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5
XM_047439513.1 XP_047295469.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
XM_047439514.1 XP_047295470.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
XM_011528359.3 XP_011526661.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
XM_005259659.4 XP_005259716.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
22002246 GOA
enables histone H3K79 methyltransferase activity IDA
IDA: 通过直接分析推断
15851025 GOA
enables histone H3K79 methyltransferase activity IMP
IMP: 通过突变表型推断
15851025 GOA
enables histone methyltransferase activity IDA
IDA: 通过直接分析推断
17707234 GOA
enables nucleic acid binding EXP
EXP: 通过实验结果推断
12628190 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20153263 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
22002246 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15851025 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22002246 GOA
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
22002246 GOA
involved in regulation of transcription regulatory region DNA binding IMP
IMP: 通过突变表型推断
22002246 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15851025 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
15851025 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DOT1L 蛋白结构

DOT1

DOT1: Histone methylation protein DOT1 (115 - 317)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1537 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1 like histone H3K79 methyltransferase

DOT1-like histone methyltransferase

DOT1-like protein

DOT1-like, histone H3 methyltransferase

H3-K79-HMTase

histone H3-K79 methyltransferase

histone methyltransferase DOT1L

lysine N-methyltransferase 4

DOT1L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DOT1L Q8TEK3 MLLT1 Homo sapiens Q03111
Anti Tag CoIP
20203130
Intra DOT1L Q8TEK3 MLLT1 Homo sapiens Q03111
Anti Tag CoIP
20153263
Intra DOT1L Q8TEK3 MLLT3 Homo sapiens P42568
Anti Tag CoIP
20203130
Intra DOT1L Q8TEK3 MLLT3 Homo sapiens P42568
Anti Tag CoIP
26496610
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DOT1L 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75283 DOT1L Protein, Human Q8TEK3-1/NP_115871.1 (G2-K416) ≥95%

关联疾病

疾病名称 别名
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15650 SGC0946 Inhibitor 99.68% 否
HY-15227 EPZ004777 Inhibitor 98.78% 否
HY-135127 Dot1L-IN-4 Inhibitor 98.98% 否
HY-135128 Dot1L-IN-5 Inhibitor 98.57% 否
HY-15227A EPZ004777 hydrochloride Inhibitor 99.46% 否
HY-101520A Dot1L-IN-1 TFA Inhibitor 98.56% 否
HY-168083 Dot1L-IN-9 Inhibitor / 否
HY-146724 Dot1L-IN-7 Inhibitor / 否
HY-145813 MU1656 Inhibitor / 否
HY-101520 Dot1L-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DOT1L VGNC VGNC:61591
Canis familiaris DOT1L VGNC VGNC:54298
Rattus norvegicus DOT1L RGD RGD:1306644
Macaca mulatta DOT1L VGNC VGNC:71901
Mus musculus DOT1L MGD MGI:2143886
Bos taurus DOT1L VGNC VGNC:50607
Others DOT1L NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z