LAMB1 - laminin subunit beta 1 Gene

中文名称：层粘连蛋白亚基β1

种属: Homo sapiens

同用名: CLM; LIS5

基因 ID: 3912 | 基因类型: protein coding

关于 LAMB1

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:107,923,799-108,003,161 (from NCBI)

This gene has 37 transcripts (splice variants), 296 orthologues, 27 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 75.7), fat (RPKM 65.2) and 23 other tissues.

功能概要

层粘连蛋白是细胞外基质糖蛋白家族，是基底膜的主要非胶原成分。它们涉及多种生物过程，包括细胞粘附、分化、迁移、信号传导、神经突生长和转移。层粘连蛋白由 3 条不相同的链组成：层粘连蛋白 alpha、beta 和 gamma (以前分别为 A、B1 和 B2) ，它们形成十字形结构，由 3 个短臂组成，每个短臂由不同的链组成，长臂由不同的链组成所有 3 条链。每条层粘连蛋白链都是由不同基因编码的多结构域蛋白质。已经描述了每条链的几种亚型。不同的 alpha、beta 和 gamma 链异构体结合产生不同的异源三聚体层粘连蛋白亚型，这些异构体按发现顺序用阿拉伯数字表示，即 alpha1beta1gamma1 异源三聚体是层粘连蛋白 1。不同链和三聚体分子的生物学功能在很大程度上是未知的, 但一些链已被证明在组织分布方面有所不同, 可能反映了体内的不同功能。该基因编码 β 链亚型层粘连蛋白，β 1。β 1 链具有 7 个结构不同的结构域，它与其他 β 链异构体共享。包含结构域 I 和 II 的 C 端螺旋区域由结构域 alpha 分隔，结构域 III 和 V 包含多个 EGF 样重复序列，结构域 IV 和 VI 具有球状构象。层粘连蛋白，β 1 在大多数产生基底膜的组织中都有表达，并且是构成层粘连蛋白 1 的 3 条链之一，层粘连蛋白 1 是从 Engelbreth-Holm-Swarm (EHS) 肿瘤中分离出来的第一个层粘连蛋白。确定了 β 1 链中涉及细胞附着、趋化性和与层粘连蛋白受体结合的序列，并显示其具有抑制转移的能力。[RefSeq 提供，2011 年 8 月]

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with Other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

LAMB1 基因产物(1)

mRNA	Protein	Name
NM_002291.3	NP_002282.2	laminin subunit beta-1 precursor

LAMB1 蛋白结构

Laminin_N

Laminin_EGF

0
300
600
900
1200
1500
1786 a.a.

蛋白主名

其他名称

laminin subunit beta-1

laminin B1 chain

LAMB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
种属内	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
种属内	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
种属内	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
种属内	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
种属内	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
种属内	LAMB1	P07942	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
种属内	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Array	32296183
种属内	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
种属间	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Crosslink	26438063
种属间	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Affinity Chrom	26438063

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lissencephaly 5

LIS5	Cobblestone Lissencephaly Without Muscular Or Ocular Involvement
Cobblestone Lissencephaly Without Muscular Or Eye Involvement	Lissencephaly Type 2 Without Muscular Or Eye Involvement
Lissencephaly Type 2 Without Muscular Or Ocular Involvement	Lissencephaly, Type 5

Cutis Laxa

Generalized Elastolysis	Loose Skin
Dermatolysis	Dermatomegaly
Cutis Laxa Syndrome

Band Heterotopia

Subcortical Band Heterotopia	Double Cortex Syndrome
Subcortical Laminar Heterotopia	Double Cortex
Band Heterotopia Of Brain	BH
Heco	Heterotopic Cortex
Familial Band Heterotopia	Dc
Dc Syndrome	Heterotopia, Subcortical Band
Sbh	Sclh
Bhy

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities

NPHS5	Nephrotic Syndrome Type 5
Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities	Nephrotic Syndrome 5 With Or Without Ocular Abnormalities
Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

Hepatocellular Clear Cell Carcinoma

Clear Cell Carcinoma Of The Liver Cells	Hepatocellular Carcinoma, Clear Cell Type
Clear Cell Hepatocellular Carcinoma

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Diffuse Mesangial Sclerosis

Familial Mesangial Sclerosis	Mesangial Sclerosis, Diffuse
Dms	Diffuse Isolated Mesangial Sclerosis
Isolated Diffuse Mesangial Sclerosis	Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis

Leiomyomatosis

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Pierson Syndrome

Microcoria-Congenital Nephrotic Syndrome	Microcoria-Congenital Nephrosis Syndrome
PIERS	Microcoria - Congenital Nephrosis
Microcoria - Congenital Nephrotic Syndrome	PIERSS

Myopathy

Muscular Diseases

Myopathies

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N1045	13-Keto-8(14)-Podocarpen-18-oic acid		/	否
HY-N1607	18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one		/	否
HY-RS07502	LAMB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-N1294	Serratenediol		/	否
HY-N3766	Diosbulbin G		/	否
HY-N4013	Imbricatoloic acid		/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	LAMB1	VGNC	VGNC:68006
Bos taurus	LAMB1	VGNC	VGNC:30772
Rattus norvegicus	LAMB1	RGD	RGD:1306311
Macaca mulatta	LAMB1	VGNC	VGNC:74228
Canis familiaris	LAMB1	VGNC	VGNC:42567
Mus musculus	LAMB1	MGD	MGI:96743

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LAMB1 - laminin subunit beta 1 Gene

关于 LAMB1

功能概要

LAMB1 基因产物(1)

LAMB1 蛋白结构

LAMB1 蛋白互作信息

关联疾病

直系同源

热门区域

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LAMB1 - laminin subunit beta 1 Gene

关于 LAMB1

功能概要

LAMB1 基因产物(1)

LAMB1 蛋白结构

LAMB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z