2. Gene
  3. MC5R - melanocortin 5 receptor Gene

MC5R - melanocortin 5 receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：黑皮质素 5 受体

种属: Homo sapiens

同用名: MC2

基因 ID: 4161 | 基因类型: protein coding

关于 MC5R

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,824,149-13,827,323 (from NCBI)

This gene has 2 transcripts (splice variants), 183 orthologues and 18 paralogues.

功能概要

该基因编码七次跨膜 G 蛋白偶联黑皮质素受体蛋白家族的成员，该蛋白家族可刺激 cAMP 信号转导。编码的蛋白质是促黑素细胞激素和促肾上腺皮质激素的受体，并被认为在皮脂生成中发挥作用。[RefSeq 提供，2010 年 6 月]

This gene encodes a member of the seven-pass transmembrane G protein-coupled Melanocortin Receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

MC5R 基因产物(1)

mRNA Protein Name
NM_005913.3 NP_005904.1 melanocortin receptor 5
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19329486 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
19329486 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MC5R 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (53 - 295)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
蛋白主名 其他名称

melanocortin receptor 5

关联疾病

疾病名称 别名
Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency

Acth Resistance

Adrenal Unresponsiveness To Acth

Hereditary Unresponsiveness To Adrenocorticotropic Hormone

Isolated Glucocorticoid Deficiency

Glucocorticoid Deficiency, Familial

Glucocorticoid Deficiency 1
Autoimmune Uveitis
Schizophrenia 4

SCZD4

Schizophrenia, Susceptibility To, 4

Schizophrenia Susceptibility Locus, Chromosome 22q11-Related

Schizophrenia Susceptibility Locus Chromosome 22-Related

Schizophrenia, Type 4
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P0227 SHU 9119 99.95% 否
HY-P0097A Nonapeptide-1 acetate salt Antagonist 98.70% 否
HY-P0097 Nonapeptide-1 Antagonist 99.04% 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MC5R VGNC VGNC:43068
Felis catus MC5R VGNC VGNC:68206
Rattus norvegicus MC5R RGD RGD:3058
Mus musculus MC5R MGD MGI:99420
Bos taurus MC5R VGNC VGNC:31296
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