MYO1C - myosin IC Gene

中文名称：肌球蛋白集成电路

种属: Homo sapiens

同用名: NMI; MMIb; myr2; MyoIC; MMI-beta

基因 ID: 4641 | 基因类型: protein coding

关于 MYO1C

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,464,186-1,492,686 (from NCBI)

This gene has 20 transcripts (splice variants), 205 orthologues, 43 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 109.9), lung (RPKM 53.1) and 23 other tissues.

功能概要

该基因编码非常规肌球蛋白家族的成员，该家族是基于肌动蛋白的分子马达。该蛋白质存在于细胞质中，并且在细胞核中也发现了一种具有独特 N 末端的亚型。核同种型与 RNA 聚合酶 I 和 II 结合并在转录起始中发挥作用。该蛋白质的小鼠直系同源物还在细胞内囊泡转运至质膜中发挥作用。已发现该基因编码不同异构体的多个转录变体。相关基因肌球蛋白 IE 在文献中被称为肌球蛋白 IC，但它是 19 号染色体上的一个独特位点。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene Myosin IE has been referred to as Myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

MYO1C 基因产物(4)

mRNA	Protein	Name
NM_001080779.2	NP_001074248.1	unconventional myosin-Ic isoform a
NM_001080950.2	NP_001074419.1	unconventional myosin-Ic isoform b
NM_001363855.1	NP_001350784.1	unconventional myosin-Ic isoform d
NM_033375.5	NP_203693.3	unconventional myosin-Ic isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21402783	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	21402783	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	24056301	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	21402783	GOA
involved in positive regulation of transcription by RNA polymerase III	IDA IDA: 通过直接分析推断	16603771	GOA
involved in protein targeting to membrane	IDA IDA: 通过直接分析推断	21402783	GOA
involved in protein targeting to membrane	IMP IMP: 通过突变表型推断	23262137	GOA
involved in regulation of bicellular tight junction assembly	IMP IMP: 通过突变表型推断	21402783	GOA
involved in vascular endothelial growth factor signaling pathway	IMP IMP: 通过突变表型推断	23262137	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of B-WICH complex	IDA IDA: 通过直接分析推断	16603771	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	21402783	GOA
located in membrane	IDA IDA: 通过直接分析推断	21402783	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	23262137	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	23262137	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYO1C 蛋白结构

Myosin_head

Myosin_TH1

0
200
400
600
800
1000
1063 a.a.

蛋白主名

其他名称

unconventional myosin-Ic

myosin-I beta

关联疾病

疾病名称

别名

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Amebiasis

Amoebiasis	Entamoebiasis
Chronic Intestinal Amebiasis	Amoebiasis, Unspecified
Amebic Colitis	Amoebic Enteritis
Infection Due To Entamoeba Histolytica	Amoebic Infection
Disease Due To Endamoebidae	Amoebiasis Nos

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08939	MYO1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MYO1C	VGNC	VGNC:68390
Macaca mulatta	MYO1C	VGNC	VGNC:75112
Bos taurus	MYO1C	VGNC	VGNC:31818
Mus musculus	MYO1C	MGD	MGI:106612
Rattus norvegicus	MYO1C	RGD	RGD:620443
Canis familiaris	MYO1C	VGNC	VGNC:43562

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MYO1C - myosin IC Gene

关于 MYO1C

功能概要

MYO1C 基因产物(4)

MYO1C 蛋白结构

关联疾病

直系同源

热门区域

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MYO1C - myosin IC Gene

关于 MYO1C

功能概要

MYO1C 基因产物(4)

MYO1C 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z