PDK3 - pyruvate dehydrogenase kinase 3 Gene

中文名称：丙酮酸脱氢酶激酶 3

种属: Homo sapiens

同用名: CMTX6; GS1-358P8.4

关于 PDK3

功能概要

丙酮酸脱氢酶 (PDH) 复合物是一种核编码的线粒体多酶复合物，可催化丙酮酸向乙酰辅酶 A 和 CO (2) 的整体转化。它提供了糖酵解和三羧酸 (TCA) 循环之间的主要联系，因此是负责调节葡萄糖代谢的主要酶之一。 PDH 的酶活性受磷酸化/去磷酸化循环的调节，磷酸化导致 PDH 失活。该基因编码的蛋白质是三种丙酮酸脱氢酶激酶之一，可通过磷酸化 E1 α 亚基来抑制 PDH 复合物。该基因主要在心脏和骨骼肌中表达。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 3 月]

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major Enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]