1. Gene
  2. DDX24 - DEAD-box helicase 24 Gene

DDX24 - DEAD-box helicase 24 Gene

中文名称:死盒解旋酶 24

种属: Homo sapiens

基因 ID: 57062 | 基因类型: protein coding

关于 DDX24

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,048,287-94,081,202 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 209 orthologues and 38 paralogues. Ubiquitous expression in testis (RPKM 90.5), adrenal (RPKM 75.8) and 25 other tissues.

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程,例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式,该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码的 DEAD box 蛋白与任何其他已知的人类 DEAD box 蛋白几乎没有相似性,但在氨基酸水平上与小鼠 Ddx24 具有很高的相似性。[RefSeq 提供,2008 年 7 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the Other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

DDX24 基因产物(1)

mRNA Protein Name
NM_020414.4 NP_065147.1 ATP-dependent RNA helicase DDX24
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22113938 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DDX24 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (216 - 511)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (608 - 681)

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  • 859 a.a.
蛋白主名 其他名称

ATP-dependent RNA helicase DDX24

DEAD (Asp-Glu-Ala-Asp) box helicase 24

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DDX24 VGNC VGNC:39851
Felis catus DDX24 VGNC VGNC:61402
Macaca mulatta DDX24 VGNC VGNC:71618
Mus musculus DDX24 MGD MGI:1351337
Bos taurus DDX24 VGNC VGNC:27960
Rattus norvegicus DDX24 RGD RGD:727929