1. Gene
  2. SLC8A2 - solute carrier family 8 member A2 Gene

SLC8A2 - solute carrier family 8 member A2 Gene

中文名称:溶质载体家族 8 成员 A2

种属: Homo sapiens

同用名: NCX2

基因 ID: 6543 | 基因类型: protein coding

关于 SLC8A2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,428,017-47,471,893 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 7 paralogues. Biased expression in brain (RPKM 19.6), endometrium (RPKM 1.5) and 1 other tissue.

功能概要

预计可使钙:阳离子反向转运蛋白活性参与调节突触后细胞溶质钙离子浓度和钙:钠反向转运蛋白活性。预计参与多个过程,包括无机阳离子跨膜转运;学习或记忆;和调节短期神经元突触可塑性。预计在几个过程的上游或内部起作用,包括调节化学突触传递;动作电位放电模式的调节;和对缺血的反应。突触前的一部分。阿尔茨海默病的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Part of presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SLC8A2 基因产物(1)

mRNA Protein Name
NM_015063.3 NP_055878.1 sodium/calcium exchanger 2 precursor
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in presynapse IDA
IDA: 通过直接分析推断
21382638 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC8A2 蛋白结构

Na_Ca_ex

Na_Ca_ex: Sodium/calcium exchanger protein (84 - 243)

Calx-beta

Calx-beta: Calx-beta domain (389 - 482)

Calx-beta

Calx-beta: Calx-beta domain (512 - 611)

Na_Ca_ex

Na_Ca_ex: Sodium/calcium exchanger protein (758 - 909)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 921 a.a.
蛋白主名 其他名称

sodium/calcium exchanger 2

Na(+)/Ca(2+)-exchange protein 2

关联疾病

疾病名称 别名
Ischemia

Acute Coronary Syndrome

Schnyder Corneal Dystrophy

Schnyder Crystalline Corneal Dystrophy

SCCD

Corneal Dystrophy, Crystalline, Of Schnyder

Corneal Dystrophy, Schnyder Type

Corneal Dystrophy Crystalline Of Schnyder

Crystalline Stromal Dystrophy

Hereditary Crystalline Stromal Dystrophy Of Schnyder

Scd

Corneal Dystrophy, Schnyder

Schnyder Crystalline Dystrophy Sine Crystals

Dystrophy, Corneal, Crystalline, Schnyder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC8A2 MGD MGI:107996
Canis familiaris SLC8A2 VGNC VGNC:46481
Rattus norvegicus SLC8A2 RGD RGD:620194
Bos taurus SLC8A2 VGNC VGNC:34936
Felis catus SLC8A2 VGNC VGNC:65429
Macaca mulatta SLC8A2 VGNC VGNC:77635