2. Gene
  3. UBA7 - ubiquitin like modifier activating enzyme 7 Gene

UBA7 - ubiquitin like modifier activating enzyme 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素样修饰激活酶 7

种属: Homo sapiens

同用名: D8; UBE2; UBE7; UBA1B; UBE1L

基因 ID: 7318 | 基因类型: protein coding

关于 UBA7

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,805,209-49,813,953 (from NCBI)

This gene has 11 transcripts (splice variants), 264 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 37.8), lymph node (RPKM 34.4) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E1 泛素激活酶家族的成员。编码的酶是一种类视黄醇靶标，可在急性早幼粒细胞白血病中触发早幼粒细胞白血病 (PML) /视黄酸受体α (RARalpha) 降解和细胞凋亡，其中它参与泛素样干扰素刺激基因 15 蛋白的结合。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating Enzyme family. The encoded Enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and Apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

UBA7 基因产物(1)

mRNA Protein Name
NM_003335.3 NP_003326.2 ubiquitin-like modifier-activating enzyme 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ISG15 activating enzyme activity IDA
IDA: 通过直接分析推断
16428300 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin-protein transferase activity EXP
EXP: 通过实验结果推断
18583345 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ISG15-protein conjugation IDA
IDA: 通过直接分析推断
16428300 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
28724761 GOA
involved in protein modification process IDA
IDA: 通过直接分析推断
16428300 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
29743376 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBA7 蛋白结构

ThiF

ThiF: ThiF family (33 - 158)

ThiF

ThiF: ThiF family (432 - 573)

UBA_e1_thiolCys

UBA_e1_thiolCys: Ubiquitin-activating enzyme active site (577 - 624)

(716 - 765)

(808 - 874)

E1_UFD

E1_UFD: Ubiquitin fold domain (881 - 1006)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1012 a.a.
蛋白主名 其他名称

ubiquitin-like modifier-activating enzyme 7

UBA1, ubiquitin-activating enzyme E1 homolog B

重组 UBA7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79454 ISG15 E1/UBE1L Protein, Human (sf9, His, Strep) P41226 (D2-L1012) ≥95%

关联疾病

疾病名称 别名
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Vexas Syndrome

VEXAS

Vexas Syndrome, Somatic

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory And Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic Syndrome

Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15325 UBA7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBA7 VGNC VGNC:78690
Bos taurus UBA7 VGNC VGNC:36566
Rattus norvegicus UBA7 RGD RGD:1308323
Felis catus UBA7 VGNC VGNC:66751
Mus musculus UBA7 MGD MGI:1349462
Canis familiaris UBA7 VGNC VGNC:48041
Others UBA7 NCBI
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