CALCR - calcitonin receptor Gene

中文名称：降钙素受体

种属: Homo sapiens

同用名: CRT; CTR; CT-R; CTR1

基因 ID: 799 | 基因类型: protein coding

关于 CALCR

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,424,486-93,574,724 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码肽激素降钙素的高亲和力受体，属于七个跨膜 G 蛋白偶联受体的亚家族。编码的蛋白质参与维持钙稳态和调节破骨细胞介导的骨吸收。该基因的多态性与骨矿物质密度的变化和骨质疏松症的发生有关。交替剪接导致多个转录本变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

CALCR 基因产物(3)

mRNA	Protein	Name
NM_001164737.3	NP_001158209.2	calcitonin receptor isoform 1 precursor
NM_001164738.2	NP_001158210.1	calcitonin receptor isoform 2 precursor
NM_001742.4	NP_001733.1	calcitonin receptor isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables amylin receptor activity	IGI IGI: 通过遗传相互作用推断	22500019	GOA
enables amylin receptor activity	IPI IPI: 通过物理相互作用推断	14722252	GOA
enables amyloid-beta binding	IDA IDA: 通过直接分析推断	22500019	GOA
NOT enables calcitonin binding	IDA IDA: 通过直接分析推断	15563840	GOA
enables calcitonin binding	IDA IDA: 通过直接分析推断	7769107	GOA
enables calcitonin binding	IPI IPI: 通过物理相互作用推断	7588285	GOA
enables calcitonin gene-related peptide receptor activity	IPI IPI: 通过物理相互作用推断	14722252	GOA
enables calcitonin receptor activity	IDA IDA: 通过直接分析推断	7588285	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7588285	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	7619207	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in amylin receptor signaling pathway	IDA IDA: 通过直接分析推断	14722252	GOA
involved in amylin receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IDA IDA: 通过直接分析推断	7588285	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in positive regulation of cAMP/PKA signal transduction	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	8078488	GOA
involved in positive regulation of gene expression	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in response to amyloid-beta	IGI IGI: 通过遗传相互作用推断	22500019	GOA
involved in response to glucocorticoid	IDA IDA: 通过直接分析推断	11250927	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of amylin receptor complex 1	IDA IDA: 通过直接分析推断	22500019	GOA
part of amylin receptor complex 2	IDA IDA: 通过直接分析推断	22500019	GOA
part of amylin receptor complex 3	IDA IDA: 通过直接分析推断	22500019	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALCR 蛋白结构

HRM

7tm_2

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

calcitonin receptor

重组 CALCR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74359	Calcitonin R Protein, Human (HEK293, hFc)	P30988 (A25-V154)	≥95%

关联疾病

疾病名称

别名

Holoprosencephaly 6

HPE6

Bone Mineral Density Quantitative Trait Locus 15

Osteoporosis	BMND15
Osteoporosis, Susceptibility To	Metaphyseal Fracture
Metaphyseal Fracture, Susceptibility To	Compression Fracture
Compression Fracture, Susceptibility To	Metaphyseal Fractures
Fractures, Compression

Root Resorption

Urolithiasis

Psoriasis 11

PSORS11	Psoriasis 11, Susceptibility To
Psoriasis Susceptibility 11	Psoriasis
Psoriasis Vulgaris	Pv

Giant Cell Reparative Granuloma

Central Giant Cell Granuloma	Central Giant Cell Reparative Granuloma Of Jaw
Central Giant Cell Granuloma	Granuloma, Giant Cell
Granuloma, Giant Cell Reparative	Giant Cell Lesion Of Small Bones
Giant Cell Granuloma, Nos

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone	Osteoclastoma
Gct Of Bone	Bone Giant Cell Tumour
Giant Cell Myeloma	Giant Cell Neoplasm Of Bone
Giant Cell Tumour Of Bone

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Colon Leiomyoma

Colonic Leiomyoma

Mixed Cerebral Palsy

Cerebral Palsy, Mixed

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Osteopetrosis

Albers-Schonberg Disease	Marble Bone Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01832	CALCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01833	Calcr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01834	Calcr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CALCR	MGD	MGI:101950
Macaca mulatta	CALCR	VGNC	VGNC:70516
Felis catus	CALCR	VGNC	VGNC:60321
Canis familiaris	CALCR	VGNC	VGNC:38664
Rattus norvegicus	CALCR	RGD	RGD:621001
Bos taurus	CALCR	VGNC	VGNC:26704
Others	CALCR	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CALCR - calcitonin receptor Gene

关于 CALCR

功能概要

CALCR 基因产物(3)

CALCR 蛋白结构

重组 CALCR 蛋白

关联疾病

直系同源

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CALCR - calcitonin receptor Gene

关于 CALCR

功能概要

CALCR 基因产物(3)

CALCR 蛋白结构

重组 CALCR 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z