2. Gene
  3. CALU - calumenin Gene

CALU - calumenin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：降钙素

种属: Homo sapiens

基因 ID: 813 | 基因类型: protein coding

关于 CALU

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,739,359-128,773,400 (from NCBI)

This gene has 6 transcripts (splice variants), 281 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 44.6), placenta (RPKM 44.1) and 25 other tissues.

功能概要

该基因的产物是一种定位于内质网 (ER) 的钙结合蛋白，它参与 ER 的蛋白质折叠和分选等功能。该蛋白属于多种 EF 手蛋白 (CERC) 家族，包括网状局部蛋白、ERC-55 和 Cab45 以及该基因的产物。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 10 月]

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

CALU 基因产物(5)

mRNA Protein Name
NM_001130674.3 NP_001124146.1 calumenin isoform b precursor
NM_001199671.2 NP_001186600.1 calumenin isoform c precursor
NM_001199672.2 NP_001186601.1 calumenin isoform d precursor
NM_001199673.2 NP_001186602.1 calumenin isoform e precursor
NM_001219.5 NP_001210.1 calumenin isoform a precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
10094503 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18688696 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
10222138 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10222138 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
10222138 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALU 蛋白结构

EF-hand_7

EF-hand_7: EF-hand domain pair (73 - 132)

EF-hand_7

EF-hand_7: EF-hand domain pair (157 - 213)

EF-hand_8

EF-hand_8: EF-hand domain pair (267 - 291)

  • 0
  • 100
  • 200
  • 315 a.a.
蛋白主名 其他名称

calumenin

IEF SSP 9302

重组 CALU 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7713 Calumenin Protein, Human (HEK293, His) O43852 (K20-F315) ≥95%

关联疾病

疾病名称 别名
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137246 CD73-IN-3 Inhibitor 99.89% 否
HY-144269 SHR902275 Inhibitor / 否
HY-149304 SARS-CoV-2-IN-40 Inhibitor / 否
HY-155014 SARS-CoV-2-IN-44 Inhibitor / 否
HY-155015 SARS-CoV-2-IN-45 Inhibitor / 否
HY-155016 SARS-CoV-2-IN-46 Inhibitor 99.77% 否
HY-156325 SARS-CoV-2-IN-62 Inhibitor / 否
HY-156337 SARS-CoV-2-IN-63 Inhibitor / 否
HY-156441 SARS-CoV-2-IN-65 Inhibitor / 否
HY-162313 NIP-22c Inhibitor / 否
HY-162492 Influenza A virus-IN-14 Inhibitor / 否
HY-162719 RH12 Inhibitor / 否
HY-RS01849 CALU Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-157805 PROTAC SARS-CoV-2 Mpro degrader-2 Degrader / 否
HY-163206 SARS-CoV-2-IN-77 Inhibitor / 否
HY-N1107 Uzarigenin / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CALU VGNC VGNC:26717
Macaca mulatta CALU VGNC VGNC:70520
Rattus norvegicus CALU RGD RGD:620383
Mus musculus CALU MGD MGI:1097158
Canis familiaris CALU VGNC VGNC:54755
Felis catus CALU VGNC VGNC:69363
Others CALU NCBI
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