ITGA8 - integrin subunit alpha 8 Gene

中文名称：整合素亚基 alpha 8

种属: Homo sapiens

基因 ID: 8516 | 基因类型: protein coding

关于 ITGA8

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,513,954-15,719,922 (from NCBI)

This gene has 3 transcripts (splice variants), 228 orthologues, 17 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 17.7), lung (RPKM 11.8) and 17 other tissues.

功能概要

整联蛋白是异二聚体跨膜受体蛋白，可介导许多细胞过程，包括细胞粘附、细胞骨架重排和细胞信号通路的激活。整合素由α和β亚基组成。该基因编码异二聚体整合素 alpha8beta1 蛋白的 alpha 8 亚基。编码的蛋白质是一种单程 1 型膜蛋白，包含多个 FG-GAP 重复序列。预计这种重复会折叠成 β 螺旋桨结构。该基因调节间充质细胞向上皮结构的募集，介导细胞间相互作用，并调节感觉和运动神经元的神经突长出。因此，整合素 alpha8beta1 蛋白在伤口愈合和器官发生中起着重要作用。该基因的突变与肾发育不良/发育不全-1 (RHDA1) 和几种慢性肾病动物模型有关。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 4 月]

Integrins are heterodimeric transmembrane Receptor Proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric Integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The Integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

ITGA8 基因产物(2)

mRNA	Protein	Name
NM_001291494.2	NP_001278423.1	integrin alpha-8 isoform 2 preproprotein
NM_003638.3	NP_003629.2	integrin alpha-8 isoform 1 preproprotein

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-matrix adhesion	IMP IMP: 通过突变表型推断	24439109	GOA
involved in kidney development	IMP IMP: 通过突变表型推断	24439109	GOA
involved in mesodermal cell differentiation	IEP IEP: 通过表达模式推断	23154389	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: 通过突变表型推断	24439109	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	24439109	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	24439109	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITGA8 蛋白结构

FG-GAP

Integrin_alpha2

Integrin_alpha

0
200
400
600
800
1000
1063 a.a.

蛋白主名

其他名称

integrin alpha-8

integrin, alpha 8

重组 ITGA8 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73869	Integrin alpha 8 beta 1 Protein, Human (HEK293, Flag, His)	P53708 (F39-L1012)&P05556-1 (Q21-D728)	≥95%

关联疾病

疾病名称

别名

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Renal Agenesis, Bilateral

Bilateral Renal Agenesis

Bilateral Renal Aplasia

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Posterolateral Myocardial Infarction

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Arrhythmogenic Right Ventricular Dysplasia, Familial, 1

Arrhythmogenic Right Ventricular Dysplasia 1	Uhl Anomaly
Arrhythmogenic Right Ventricular Cardiomyopathy 1	Arvc1
ARVD1	Cardiomyopathy Right Ventricular Dilated
Dysplasia, Arrhythmogenic Right Ventricular, Type 1

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06955	ITGA8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ITGA8	VGNC	VGNC:42130
Mus musculus	ITGA8	MGD	MGI:109442
Macaca mulatta	ITGA8	VGNC	VGNC:73782
Felis catus	ITGA8	VGNC	VGNC:67846
Rattus norvegicus	ITGA8	RGD	RGD:621634
Bos taurus	ITGA8	VGNC	VGNC:30319
Others	ITGA8	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ITGA8 - integrin subunit alpha 8 Gene

关于 ITGA8

功能概要

ITGA8 基因产物(2)

ITGA8 蛋白结构

重组 ITGA8 蛋白

关联疾病

直系同源

热门区域

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ITGA8 - integrin subunit alpha 8 Gene

关于 ITGA8

功能概要

ITGA8 基因产物(2)

ITGA8 蛋白结构

重组 ITGA8 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z