2. Gene
  3. ADAM15 - ADAM metallopeptidase domain 15 Gene

ADAM15 - ADAM metallopeptidase domain 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 15

种属: Homo sapiens

同用名: MDC15

基因 ID: 8751 | 基因类型: protein coding

关于 ADAM15

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,051,316-155,062,775 (from NCBI)

This gene has 32 transcripts (splice variants), 192 orthologues and 20 paralogues. Ubiquitous expression in skin (RPKM 41.3), esophagus (RPKM 32.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 ADAM (一种解整合素和金属蛋白酶) 蛋白质家族的成员。 ADAM 家族成员是已知参与细胞粘附和细胞因子和粘附分子的蛋白水解胞外域加工的 I 型跨膜糖蛋白。该蛋白质包含多个功能结构域，包括锌结合金属蛋白酶结构域、解整合素样结构域以及 EGF 样结构域。通过其解联蛋白样结构域，该蛋白与整合素 β 链 β 3 特异性相互作用。它还以磷酸化依赖性方式与 Src 家族蛋白酪氨酸激酶相互作用，表明该蛋白也可能在细胞间粘附中发挥作用就像在蜂窝信号中一样。已经观察到编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the Integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ADAM15 基因产物(9)

mRNA Protein Name
NM_001261464.2 NP_001248393.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 7 preproprotein
NM_001261465.2 NP_001248394.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 8 preproprotein
NM_001261466.2 NP_001248395.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 9 preproprotein
NM_003815.5 NP_003806.3 disintegrin and metalloproteinase domain-containing protein 15 isoform 2 preproprotein
NM_207191.3 NP_997074.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 1 preproprotein
NM_207194.3 NP_997077.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 3 preproprotein
NM_207195.3 NP_997078.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 4 preproprotein
NM_207196.3 NP_997079.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 5 preproprotein
NM_207197.3 NP_997080.1 disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
10531379 GOA
enables immunoglobulin receptor binding IPI
IPI: 通过物理相互作用推断
12777399 GOA
enables integrin binding IMP
IMP: 通过突变表型推断
22505472 GOA
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
12777399 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10531379 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in apoptotic process IDA
IDA: 通过直接分析推断
22505472 GOA
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: 通过直接分析推断
22505472 GOA
involved in immune response to tumor cell IDA
IDA: 通过直接分析推断
22505472 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
22505472 GOA
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
22505472 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
22505472 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
22505472 GOA
involved in negative regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
22505472 GOA
involved in negative regulation of receptor binding IMP
IMP: 通过突变表型推断
22505472 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
22505472 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
22505472 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM15 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (62 - 156)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (213 - 412)

Disintegrin

Disintegrin: Disintegrin (430 - 504)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (508 - 623)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 863 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 15

MDC-15

重组 ADAM15 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75533 ADAM15 Protein, Human (HEK293, His) Q13444 (D207-T696) ≥95%
HY-P75534 ADAM15 Protein, Human (CHO, His) Q13444 (D207-T696) ≥95%

关联疾病

疾病名称 别名
Sorsby Fundus Dystrophy

SFD

Fundus Dystrophy, Pseudoinflammatory, Of Sorsby

Sorsby'S Fundus Dystrophy

Macular Dystrophy, Hemorrhagic

Hemorrhagic Macular Dystrophy

Pseudoinflammatory Fundus Dystrophy Of Sorsby

Sorsby'S Pseudoinflammatory Macular Dystrophy

Sorsby Pseudoinflammatory Fundus Dystrophy

Dystrophy, Fundus, Sorsby
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00270 ADAM15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ADAM15 VGNC VGNC:37575
Macaca mulatta ADAM15 VGNC VGNC:69477
Felis catus ADAM15 VGNC VGNC:59576
Bos taurus ADAM15 VGNC VGNC:25606
Rattus norvegicus ADAM15 RGD RGD:620402
Mus musculus ADAM15 MGD MGI:1333882
Others ADAM15 NCBI
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