ADAM15 蛋白, Human (HEK293, His)

ADAM15 protein is an active metalloprotease involved in wound healing, cell interactions, and T cell recruitment. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. ADAM15 Protein, Human (HEK293, His) is the recombinant human-derived ADAM15 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM15 Protein, Human (HEK293, His) is 490 a.a., with molecular weight of 65-70 kDa.

ADAM15 蛋白是一种活性金属蛋白酶，具有分解明胶和分解胶原的活性。它参与多种生物过程，包括伤口愈合、异型上皮内细胞/T 细胞相互作用和同型 T 细胞聚集。ADAM15 还抑制 β-1 整合素介导的气道平滑肌细胞的粘附和迁移。它可能通过 ERK1/2 失活来减少 α-v/β-1 整合素的表达，从而抑制细胞向纤连蛋白运动。此外，ADAM15 响应生长因子剥夺而裂解 E-钙粘蛋白，并在肾小球细胞迁移和病理性新血管形成中发挥作用。它也可能在软骨重塑中发挥作用。在精子附睾成熟和顶体反应期间，ADAM15 可能会经历蛋白水解过程。其解整合素结构域表明可能参与精卵结合。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-His

Q13444 (D207-T696)

8751  [NCBI]

65-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.