CREG1 - cellular repressor of E1A stimulated genes 1 Gene

中文名称：E1A 刺激基因 1 的细胞阻遏物

种属: Homo sapiens

同用名: CREG

关于 CREG1

功能概要

腺病毒 E1A 蛋白既可以激活也可以抑制基因表达，从而促进细胞增殖并抑制分化。由该基因编码的蛋白质拮抗 E1A 的转录激活和细胞转化。该蛋白与 E1A 具有有限的序列相似性，并在体外结合一般转录因子 TBP 和肿瘤抑制因子 pRb。该基因可能有助于细胞生长和分化的转录控制。[RefSeq 提供，2008 年 7 月]

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]