1. Gene
  2. MUC16 - mucin 16, cell surface associated Gene

MUC16 - mucin 16, cell surface associated Gene

中文名称:粘蛋白 16,细胞表面相关

种属: Homo sapiens

同用名: CA125

基因 ID: 94025 | 基因类型: protein coding

关于 MUC16

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,848,844-9,010,437 (from NCBI)

This gene has 5 transcripts (splice variants), 85 orthologues and is associated with 139 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是粘蛋白家族的一员。粘蛋白是高分子量的 O-糖基化蛋白质,在形成保护性粘液屏障方面发挥重要作用,存在于上皮细胞的顶端表面。编码的蛋白质是一种膜栓粘蛋白,在其氨基末端包含一个胞外结构域、一个大的串联重复结构域和一个具有短胞质结构域的跨膜结构域。氨基末端高度糖基化,而重复区域包含 156 个富含丝氨酸、苏氨酸和脯氨酸的氨基酸重复单元。散布在重复序列中的是海胆精子蛋白肠激酶和集聚蛋白 (SEA) 模块、富含亮氨酸的重复序列和锚蛋白 (ANK) 重复序列。这些区域一起形成了胞外域,并且在靠近跨膜域的 SEA 模块附近发现了一个潜在的切割位点。这种蛋白质被认为在形成屏障、保护上皮细胞免受病原体侵害方面发挥作用。该基因的产物已被用作不同癌症的标志物,较高的表达水平与较差的结果相关。[RefSeq 提供,2017 年 5 月]

This gene encodes a protein that is a member of the Mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered Mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

MUC16 基因产物(4)

mRNA Protein Name
NM_001401501.2 NP_001388430.1 mucin-16 isoform 2 precursor
NM_001414686.1 NP_001401615.1 mucin-16 isoform 1 precursor
NM_001414687.1 NP_001401616.1 mucin-16 isoform 3
NM_024690.2 NP_078966.2 mucin-16 isoform 4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14676194 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12766047 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MUC16 蛋白结构

SEA

SEA: SEA domain (12074 - 12171)

SEA

SEA: SEA domain (12231 - 12325)

SEA

SEA: SEA domain (12388 - 12483)

SEA

SEA: SEA domain (12544 - 12642)

SEA

SEA: SEA domain (12699 - 12797)

SEA

SEA: SEA domain (12855 - 12944)

SEA

SEA: SEA domain (13011 - 13108)

SEA

SEA: SEA domain (13167 - 13270)

SEA

SEA: SEA domain (13324 - 13426)

SEA

SEA: SEA domain (13479 - 13583)

SEA

SEA: SEA domain (13635 - 13739)

SEA

SEA: SEA domain (13793 - 13893)

SEA

SEA: SEA domain (13922 - 14029)

SEA

SEA: SEA domain (14076 - 14169)

SEA

SEA: SEA domain (14202 - 14272)

SEA

SEA: SEA domain (14319 - 14423)

  • 0
  • 2300
  • 4600
  • 6900
  • 9200
  • 11500
  • 14507 a.a.
蛋白主名 其他名称

mucin-16

CA125 ovarian cancer antigen

重组 MUC16 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7696 CA125 Protein, Human (HEK293, His) Q8WXI7 (G12660-M12923) ≥95%
HY-P72347 CA125 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q8WXI7 (G12660-M12923) ≥95%
HY-P78178 CA125 Protein, Human (Biotinylated, HEK293, His-Avi) Q8WXI7 (G12660-M12923) ≥95%
HY-P78493 CA125 Protein, Human (HEK293, His-Avi) Q8WXI7 (G12660-M12923) ≥95%
HY-P700960 CA125 Protein, Human (Biotinylated, 685a.a, HEK293, His-Avi) Q8WXI7 (D12783-S13467) ≥95%
HY-P700961 CA125 Protein, Human (685a.a, HEK293, His) Q8WXI7 (D12783-S13467) ≥95%

关联疾病

疾病名称 别名
Clear Cell Adenocarcinoma

Mesonephroma

Water-Clear Cell Adenocarcinoma

Adenocarcinoma, Clear Cell

Malignant Mesonephroma

Mesonephroid Clear Cell Carcinoma

Mesonephroma, Malignant

Water-Clear Cell Carcinoma

Wolffian Duct Neoplasm

Adenocarcinoma Clear Cell

Mesonephric Tumor

Serous Cystadenocarcinoma

Serous Adenocarcinoma

Cystadenocarcinoma, Serous

Serous Carcinoma

Cystadenocarcinoma Serous

Ovarian Cyst

Ovarian Cysts

Cystadenocarcinoma
Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma

Infiltrating Papillary Adenocarcinoma

Adenocarcinoma Papillary

Adenocarcinoma, Papillary

Endodermal Sinus Tumor

Yolk Sac Tumor

Endodermal Sinus Tumour

Hepatoid Yolk Sac Tumour

Infantile Embryonal Carcinoma

Yolk Sac Neoplasm

Yolk Sac Tumour

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Ovarian Cystadenoma

Cystoma Serosum Simplex

Simple Cystoma Of Ovary

Simple Cystoma Of The Ovary

Peritonitis

Retractile Mesenteritis

Sclerosing Mesenteritis

Acute Generalized Peritonitis

Primary Bacterial Peritonitis

Idiopathic Sclerosing Mesenteritis

Mesenteric Panniculitis

Peritoneal Retractile Mesenteritis

Liposclerotic Mesenteritis

Mesenteric Fibromatosis

Mesenteric Lipodystrophy

Mesenteric Lipogranuloma

Fibromatosis, Abdominal

Peritoneum Inflammation

Peritonitis Of Undetermined Cause

Peritonitis Of Unspecified Cause

Pelviperitonitis

Pelvic Peritonitis, Nos

Generalised Peritonitis Nos

Abdominal Peritonitis

Acute Idiopathic Peritonitis

Acute Lesser Sac Peritonitis

Acute Peritoneal Inflammation

Diffuse Peritonitis

Peritoneal Inflammation

Acute Primary Peritonitis

Pneumococcal Peritonitis

Pericardial Effusion

Noninflammatory Pericardial Effusion

Pericardium Effusion

Tuberculous Peritonitis

Peritonitis, Tuberculous

Peritonitis Tuberculous

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Keratoconjunctivitis
Lymphatic Malformation 5

Meige Syndrome

Meige Disease

Meige Lymphedema

Lymphedema Praecox

Lymphedema, Late-Onset

Late-Onset Lymphedema

LMPH2

Meigs Syndrome

LMPHM5

Lymphedema, Hereditary, Ii, Formerly

Lmph2, Formerly

Hereditary Lymphedema Ii

Demons-Meigs Syndrome

Hereditary Lymphedema Type Ii

Lymphedema, Hereditary, 2

Lymphedema, Hereditary, Ii

Meige'S Disease

Fibroma
Adenofibroma
Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary

Corpus Luteum Cyst

Cystic Corpus Luteum

Luteal Cystic Ovary Disease

Lutein Cyst

Granulosa Lutein Cyst

Obstructive Jaundice

Jaundice, Obstructive

Cholestatic Jaundice

Cholestatic Jaundice Syndrome

Obstructive Hyperbilirubinemia

Jaundice Obstructive

Jaundice Cholestatic

Mucinous Cystadenocarcinoma

Cystadenocarcinoma, Mucinous

Pseudomucinous Cystadenocarcinoma

Cystadenocarcinoma Mucinous

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Pseudomyxoma Peritonei

Adenomucinosis

Gelatinous Ascites

Pmp

Mucinous Ascites

Syndrome Of Pseudomyxoma Peritonei

Filamentary Keratitis
Ovarian Serous Cystadenocarcinoma

Serous Cystadenoma

Cystadenoma Serous

Cystadenoma, Serous

Bronchogenic Cyst
Adenomyosis

Endometriosis Of Uterus

Endometriosis Interna

Endometriosis Of Myometrium

Endometriosis, Myometrium

Uterine Adenomyosis

Adenomyosis Uteri

Internal Endometriosis

Ovarian Brenner Tumor

Benign Ovarian Brenner Tumor

Brenner Tumor

Benign Ovarian Brenner Tumour

Ovarian Brenner Tumour

Brenner Tumor Of Ovary

Benign Brenner Tumor

Leiomyosarcoma

Leiomyosarcomas

Cystadenoma

Cystoma

Craniopharyngioma

Pleurisy
Struma Ovarii
Myxedema
Mesothelioma, Malignant

Malignant Mesothelioma

Pleural Mesothelioma

MESOM

Mesothelioma, Somatic

Advanced Malignant Mesothelioma

Asbestos-Related Malignant Mesothelioma

Diffuse Malignant Mesothelioma

Malignant Tumor Of Mesothelium

Malignant Mesothelioma, Susceptibility To

Mesothelioma Diffuse Malignant

Mesothelioma

Malignant Pleural Mesothelioma

Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis

Thygeson Superficial Punctate Keratitis

Thygeson'S Superficial Punctate Keratitis

Thygeson Superficial Punctate Keratopathy

Punctate Epithelial Keratitis

Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Opisthorchiasis

Infection By Opisthorchis

Infection Due To Opisthorchis

Infection Due To Cat Liver Fluke

Infection By Cat Liver Fluke

Opisthorchiosis

Cat Liver Fluke Fever

Cat Liver Fluke Disease

Opisthorchis Infestation

Cat Liver Fluke Infestation

Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos

Colorectal Cancer, Hereditary Nonpolyposis, Type 8

HNPCC8

Hereditary Nonpolyposis Colorectal Cancer Type 8

Hereditary Non-Polyposis Colorectal Cancer 8

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8

Polycystic Liver Disease 1 With Or Without Kidney Cysts

Polycystic Liver Disease 1

PCLD1

Cyst

Liver Disease, Polycystic, Type 1

Polycystic Liver Disease

Cervical Adenocarcinoma

Adenocarcinoma Cervix Uteri

Adenocarcinoma Of Cervix

Adenocarcinoma Of The Uterine Cervix

Adenocarcinoma Of The Cervix Uteri

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Conjunctivochalasis
Cicatricial Pemphigoid

Mucous Membrane Pemphigoid

Ocular Pemphigoid

Benign Mucous Membrane Pemphigoid

Benign Mucous Membrane Pemphigoid With Ocular Involvement

Benign Mucosal Pemphigoid

Pemphigoid, Benign Mucous Membrane

Cicatricial Pemphigoid With Ocular Involvement

Ocular Pemphigus

Cicatricial Pemphigoid Disease

Mucosal Pemphigoid

Mucosynechial Pemphigoid

Pemphigoid Cicatricial

Cicatricial Pemphigoid Involving The Eye

Ocular Cicatricial Pemphigoid

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Dry Eye Syndrome

Dry Eye Syndromes

Dry Eye Disease

Tear Film Insufficiency

Xerophthalmia

Blepharitis
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Fallopian Tube Endometrioid Adenocarcinoma

Endometrioid Carcinoma Of The Fallopian Tube

Fallopian Tube Endometrioid Cancer

Fallopian Tube Endometrioid Neoplasm

Fallopian Tube Endometrioid Tumor

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Ovary Adenocarcinoma

Ovarian Adenocarcinoma

Adenocarcinoma Of The Ovary

Ovarian Adenoacanthoma

Adenocarcinoma Of Ovary

Ovarian Cystadenocarcinoma

Cystadenocarcinoma Of Ovary

Cystadenocarcinoma Of The Ovary

Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Malignant Ovarian Surface Epithelial-Stromal Tumor

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MUC16 RGD RGD:1308422
Mus musculus MUC16 MGD MGI:1920982