CD79B - CD79b molecule Gene

中文名称：CD79b 分子

种属: Homo sapiens

同用名: B29; IGB; AGM6; Igbeta

基因 ID: 974 | 基因类型: protein coding

关于 CD79B

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,928,740-63,932,331 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 71 phenotypes. Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues.

功能概要

淋巴细胞抗原受体是一种多聚体复合物，包括抗原特异性成分、表面免疫球蛋白 (Ig) 。表面 Ig 与另外两种蛋白质 Ig-α 和 Ig-β 非共价结合，这两种蛋白质是 B 细胞抗原受体的表达和功能所必需的。该基因编码 B 细胞抗原成分的 Ig-β 蛋白。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CD79B 基因产物(4)

mRNA	Protein	Name
NM_000626.4	NP_000617.1	B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor
NM_001039933.3	NP_001035022.1	B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor
NM_001329050.2	NP_001315979.1	B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor
NM_021602.4	NP_067613.1	B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IDA IDA: 通过直接分析推断	14967045	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	20696394	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of B cell receptor complex	IDA IDA: 通过直接分析推断	35981043	GOA
part of IgM B cell receptor complex	IDA IDA: 通过直接分析推断	35981043	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD79B 蛋白结构

V-set

ITAM

0
100
200
230 a.a.

蛋白主名

其他名称

B-cell antigen receptor complex-associated protein beta chain

B-cell-specific glycoprotein B29

重组 CD79B 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70541	CD79B Protein, Human (HEK293, His)	P40259 (A29-D159)	≥95%
HY-P70768	CD79B Protein, Human (Biotinylated, HEK293, His-Avi)	P40259 (A29-D159)	≥95%
HY-P75386	CD79 Protein, Human (HEK293, Flag-His)	P11912 (L33-R143)&P40259 (A29-D159)	≥95%
HY-P78415	CD79B Protein, Human (HEK293, His-Avi)	P40259 (A29-D159)	≥95%

关联疾病

疾病名称

别名

Agammaglobulinemia 6, Autosomal Recessive

Agammaglobulinemia 6	AGM6
Agammaglobulinemia, Autosomal Recessive, Due To Cd79b Defect	Agammaglobulinemia Autosomal Recessive Due To Cd79b Defect
Agammaglobulinemia, Type 6, Autosomal Recessive

Agammaglobulinemia, Non-Bruton Type

Autosomal Agammaglobulinemia

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Central Nervous System Lymphoma

Microglioma	Primary Cns Lymphoma
Cns Lymphoma	Primary Central Nervous System Lymphoma

Lambda 5 Deficiency

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, B-Cell Type
B-Pll	Doid:0081041
Leukemia, Prolymphocytic, B-Cell	Pll- [Prolymphocytic Leukaemia]
Prolymphocytic Leukaemia	Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll	B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Icdo:9823/3	Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Small Cell B-Cell Lymphoma

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th	High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements
High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Plasmacytoma

Solitary Plasmacytoma	Solitary Myeloma
Myeloma - Solitary	Myeloma, Solitary
Plasmacytoma - Category	Solitary Osseous Plasmacytoma
Solitary Plasmacytoma Without Mention Of Remission	Localised Malignant Plasma Cell Tumour Nos
Plasmacytoma Nos

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma	Mzl
Mucosa-Associated Lymphoid Tissue Lymphoma

Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye

Cerebral Lymphoma

Primary Cerebral Lymphoma	Brain Primary Lymphoma
Primary Lymphoma Of Cerebrum

Ecthyma

Adult Lymphoma

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia	XLA
Bruton Type Agammaglobulinemia	Bruton'S Agammaglobulinemia
Bruton-Type Agammaglobulinemia	Agmx1
Imd1	Agammaglobulinemia, X-Linked 1
Btk-Deficiency	Agammaglobulinemia
Hypogammaglobulinemia	Agammaglobulinemia, X-Linked, Type 1
Immunodeficiency 1	Bruton Agammaglobulinemia Tyrosine Kinase Deficiency
Bruton Disease	Bruton'S Agammaglobulinaemia
Bruton'S Sex-Linked Agammaglobulinemia	Bruton'S Type Agammaglobulinemia
Btk Deficiency	Agammaglobulinemia, Btk
Agammaglobulinemia, Bruton Tyrosine Kinase	Congenital Agammaglobulinemia
Immunodeficiency Type 1	X-Linked Agammaglobulinemia Type 1

Plasma Protein Metabolism Disease

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Waldenström Macroglobulinemia	Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma	Waldenstrom'S Macroglobulinaemia
Waldenstrom'S Syndrome	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99042	Polatuzumab		98.57%	Phase 3
HY-132253	Polatuzumab vedotin		98.83%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-132253A	Polatuzumab vedotin (solution)		/	否
HY-163295	BTK degrader-1	Degrader	/	否
HY-RS02268	CD79B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99656	Iladatuzumab		96.97%	否
HY-P99657	Iladatuzumab vedotin		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CD79B	VGNC	VGNC:27047
Mus musculus	CD79B	MGD	MGI:96431
Canis familiaris	CD79B	VGNC	VGNC:38974
Macaca mulatta	CD79B	VGNC	VGNC:99136
Rattus norvegicus	CD79B	RGD	RGD:620012
Others	CD79B	NCBI