2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Polatuzumab vedotin

Polatuzumab vedotin 

目录号: HY-132253 纯度: 98.83%
COA

摩尔计算器

Polatuzumab vedotin 是一种靶向 CD79b 的抗体活性分子偶联物。它由一种人源化抗 CD79b IgG1 单克隆抗体与一种有效的微管抑制剂单甲基 auristatin E (MMAE) 相连，是一种有效的微管抑制剂。Polatuzumab vedotin 具有研究大 B 细胞淋巴瘤 (LBCL) 的潜力。

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Polatuzumab vedotin Chemical Structure

Polatuzumab vedotin Chemical Structure

CAS No. : 1313206-42-6

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1 mg ￥8810
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5 mg ￥23500
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Other Forms of Polatuzumab vedotin:

Polatuzumab vedotin 相关抗体

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  • 生物活性

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生物活性

Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL)[1].

体内研究
(In Vivo)

Polatuzumab vedotin (0.3, 1, 3, 6, 12 mg/kg; i.v.; once) shows anti-tumor in a mouse tumour xenograft model of human diffuse large B‐cell lymphoma WSU‐DLCL2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (human diffuse large B-cell lymphoma WSU-DLCL2)[2]
Dosage: 0.3, 1, 3, 6, 12 mg/kg
Administration: I.v.; once
Result: Showed dose-dependent tumour growth inhibition.
Clinical Trial
CAS 号
性状

固体

颜色

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运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Polatuzumab vedotin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polatuzumab vedotin1313206-42-6Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesantibody-drugLarge B-cell lymphomasanti-tumorInhibitorinhibitorinhibit

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