2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GM-60186

GM-60186 是一种 5-HT 受体 2B (HTR2B) 抑制剂，IC50 为 257 nM。GM-60186 可显著抑制结直肠癌的增殖和迁移。

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GM-60186 Chemical Structure

GM-60186 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

GM-60186 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration[1].

IC50 & Target[1]

5-HT2B Receptor

257 nM (IC50)

体外研究
(In Vitro)

GM-60186 (50-500 nM；72 小时) 可有效抑制结直肠癌 (CRC) 细胞的增殖[1]。
GM-60186 (500 nM；24-48 小时) 可有效抑制结直肠癌的迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GM-60186 相关抗体:

Cell Viability Assay[1]

Cell Line: COLO-205, MC38, CT26 and Caco2 cells
Concentration: 0, 50, 100, and 500 nM
Incubation Time: 72 hours
Result: Demonstrated effective inhibition of cell proliferation in these CRC cell lines.

Cell Migration Assay [1]

Cell Line: COLO-205, CT26 and MC38 cells
Concentration: 500 nM
Incubation Time: 24, and 48 h
Result: Inhibited colorectal cancer migration.
体内研究
(In Vivo)

GM-60186（10-20 mg/kg；腹腔注射；每日；持续 20 天）可显著减小异种移植小鼠模型中的肿瘤大小和重量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Homozygous male BALB/c nude mice (CAnN.Cg-Foxn1 nu/Crl; 8-week-old) injected with COLO-205 cells[1]
Dosage: 10 mg/kg; 20 mg/kg
Administration: IP; daily; for 20 days
Result: Significantly reduced tumor size and weight.
分子量

504.59

Formula

C30H33FN2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GM-60186 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GM-60186GM60186GM 601865-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorHTR2B inhibitorcolorectal cancermigrationInhibitorinhibitorinhibit

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产品名称：
GM-60186
目录号：
HY-169229
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