2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. K-Ras(G12C) inhibitor 9

K-Ras (G12C) inhibitor 9 是 K-Ras (G12C) 的变构抑制剂。

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K-Ras(G12C) inhibitor 9 Chemical Structure

K-Ras(G12C) inhibitor 9 Chemical Structure

CAS No. : 1469337-91-4

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规格 价格 是否有货 数量
2 mg ￥1142
1 - 2 周
5 mg   询价  
10 mg   询价  

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K-Ras(G12C) inhibitor 9 相关抗体

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K-Ras H-Ras N-Ras Ras

  • 生物活性

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  • 参考文献

生物活性

K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
5.2 μM
Compound: SH-9
Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
MRC5 IC50
10.3 μM
Compound: SH-9
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
NCI-H2228 IC50
7.2 μM
Compound: SH-9
Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
NCI-H23 IC50
3 μM
Compound: SH-9
Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
NCI-H358 IC50
4.4 μM
Compound: SH-9
Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
NCI-H441 IC50
21.5 μM
Compound: SH-9
Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
SK-LU-1 IC50
22.8 μM
Compound: SH-9
Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 36228411]
分子量

513.78

Formula

C16H21ClIN3O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (191 KB)

产品使用指南 (1538 KB)
参考文献

K-Ras(G12C) inhibitor 9 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras(G12C) inhibitor 91469337-91-4RasInhibitorinhibitorinhibit

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