Ras Inhibitors

KRAS(G12C)

KRas G12D, Kd: 0.2 pM

KRas G12C

KRas G12D

KRas G12D, Ki: 0.083 nM

KRAS(G12C)

H-Ras

NRAS rG4

KRAS-SOS1, IC₅₀: 6 nM

KRAS(G12C), IC₅₀: 450 nM
KRAS(G12C), Kd: 750 nM

K-Ras(G12C), IC₅₀: <0.01 μM

KRAS(G12D)

KRAS(G12C)

KRAS-SOS1, IC₅₀: 46 nM

KRAS-SOS1, IC₅₀: 21 nM

KRAS(G12C), DC₅₀: 0.25-0.76 μM

KRas G12C

KRAS(G12C)

KRas G12C

KRas G12D, IC₅₀: 9 nM
KRas G12S, IC₅₀: 11 nM
KRas G12C, IC₅₀: 6 nM
KRas Q61H, IC₅₀: 12 mM
KRas G12V, IC₅₀: 29 mM
K-Ras WT, IC₅₀: 32 nM

KRAS(G12C)

K-Ras WT

KRAS(G12C)

KRas G12C

KRAS(G12D)

KRAS(G12C), IC₅₀: 2.5 μM

KRAS (G12C)
KRAS (G12C/Y96D)

K-Ras WT, EC₅₀: 0.28 μM
KRAS(G12C), EC₅₀: 0.63 μM
KRas G12D, EC₅₀: 0.37 μM
KRas Q61H, EC₅₀: 0.74 μM

Ras, IC₅₀: 10 nM

KRas G12D, IC₅₀: 90 nM

KRAS(G12C)

KRas G12D, Kd: 33 nM

KRas G12C, EC₅₀: 140 nM
KRas G12D, EC₅₀: 109 nM
KRas G12V, EC₅₀: 154 nM
KRas G12S, EC₅₀: 155 nM
KRas Q61H, EC₅₀: 175 nM
K-Ras WT, EC₅₀: 106 nM

Ras

K-RAS

SOS1, IC₅₀: 5 nM

KRas G12C, IC₅₀: 40 nM

KRAS(G12C)

KRAS-SOS1, IC₅₀: 7.0 nM

H-Ras

KRas G12C, IC₅₀: 18 nM

KRas G12C

KRas G12C

Ras

KRas G12C, IC₅₀: 5 nM

KRAS(G12C)

KRas G12D

KRAS(G12C)

KRAS(G12C)

KRas G12C, IC₅₀: 57 nM

K-RAS

KRas G12D

KRAS(G12D), IC₅₀: 1.6 μM

KRas G12D, IC₅₀: <500 nM

KRAS-PDEδ

KRAS(G12C)

KRas G12C

KRAS(G12C)

KRas G12C

KRAS(G12C)

KRAS(G12C)

KRAS(G12C)

KRAS (G12C)

KRas G12D, IC₅₀: <500 nM

KRas G12C

KRas G12C, IC₅₀: 0.249 μM

KRas G12C

KRas G12C, IC₅₀: 5 nM

KRAS(G12C), IC₅₀: <10 nM (^[1])

KRas G12C, IC₅₀: 97 nM

KRas G12C, IC₅₀: 0.028 μM

KRas G12C, IC₅₀: 0.457 μM

KRas G12C

KRas G12S

SOS1-G12D, IC₅₀: 11.6 nM
SOS1-G12V, IC₅₀: 40.7 nM

KRAS(G12D), IC₅₀: 2.4 μM

KRas G12C

KRAS(G12C)

K-Ras WT

KRAS(G12C)

KRas G12D, Kd: 0.019 nM
KRas G12C, Kd: 0.019 nM
KRas G12V, Kd: 0.096 nM

KRas G12V, IC₅₀: 0.371 nM

KRAS G12C-SOS1, IC₅₀: 116.5 nM

KRas G12C, IC₅₀: 0.883 μM

KRas G12D

KRas G12C

KRas G12C, IC₅₀: 3.37 μM

KRas G12V, IC₅₀: < 100 nM
K-Ras WT, IC₅₀: < 100 nM
KRas G12R, IC₅₀: < 100 nM

KRas G12C

KRas G12D, IC₅₀: 9.79 nM
KRas G12V, IC₅₀: 6.03 nM

K-RAS

KRas G12D

H-Ras

Ras

KRAS(G12C)

KRas G12C

KRas G12C

KRas G12D, IC₅₀: 0.7 nM

SOS1-G12D, IC₅₀: 20 nM
SOS1-G12V, IC₅₀: 67 nM

KRas G12C

KRas G12C, EC₅₀: 140 nM
KRas G12D, EC₅₀: 109 nM
KRas G12V, EC₅₀: 154 nM
KRas G12S, EC₅₀: 155 nM
KRas Q61H, EC₅₀: 175 nM
K-Ras WT, EC₅₀: 106 nM

KRas G12C

K-RAS, : 6.4 nM

KRAS(G12C)

KRas G12C, IC₅₀: 0.537 μM

KRas G12V, IC₅₀: <100 nM

KRAS G12C-SOS1, IC₅₀: 13 nM

K-RAS, IC₅₀: 1.4 nM

KRas G12C

K-RAS

SOS1, Kd: 95.9 nM

KRas G12C, IC₅₀: 0.954 μM

KRas G12C, IC₅₀: 0.172 μM

KRas G12C, IC₅₀: < 100 nM
K-Ras WT, IC₅₀: < 100 nM
KRas G12R, IC₅₀: < 100 nM

KRas G12D, IC₅₀: 2.75 nM
KRas G12V, IC₅₀: 2.89 nM

KRAS(G12C), IC₅₀: 0.21 μM (KRAS G12C/SOS1 binding assay)

KRAS(G12C)

KRas G12C

KRas G12C

K-Ras WT

K-RAS

KRas G12C, IC₅₀: 639.91 nM

KRas G12D

K-Ras(G12C)

KRas G12C

KRas G12C, IC₅₀: 7 nM

KRas G12C

SOS1

KRAS(G12C), IC₅₀: 46.7 nM

KRas G12C, IC₅₀: 1.3 nM
KRas G12D, IC₅₀: 4.7 nM
KRas G12V, IC₅₀: 0.3 nM

KRas G12C, IC₅₀: 4.74 μM

KRAS-C12C/SOS1, IC₅₀: 56 nM

K-Ras WT, Kd: 0.004 nM
KRas G12D, Kd: 0.041 nM
KRas G12C, Kd: 0.019 nM
KRas G12V, Kd: 0.144 nM

KRAS(G12C), IC₅₀: 1.16 μM

K-RAS, : 2 nM

KRas G12D, IC₅₀: <100 nM

SOS1-G12D, IC₅₀: 14.9 nM
SOS1-G12V, IC₅₀: 73.3 nM

KRas G12D

KRas G12D, IC₅₀: 0.007 μM

NRAS rG4, Kd: 2.31 μM

K-RAS

KRas G12C

KRAS(G12C)

KRas G12C

K-RAS

K-RAS

KRas G12C

K-Ras(G12C)

KRas G12C

KRas G12C

KRas G12C

KRas G12C