2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 20

KRAS G12D inhibitor 20 (Compound 14) 是一个选择性的 G12D KRAS 抑制剂。KRAS G12D inhibitor 20 具有抗肿瘤活性。

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KRAS G12D inhibitor 20 Chemical Structure

KRAS G12D inhibitor 20 Chemical Structure

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KRAS G12D inhibitor 20 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS G12D inhibitor 20 (Compound 14) is a selective G12D KRAS inhibitor. KRAS G12D inhibitor 20 has antitumor activity[1].

IC50 & Target[1]

KRas G12D

 

体外研究
(In Vitro)

KRAS G12D inhibitor 20 (72 h) 对 PANC-1 (KRAS G12D) 和 BxPC3 (KRASwt) 人胰腺癌细胞系显示出抗增殖活性，IC50s 分别为 5.5 和 8.2 μM，对正常细胞毒性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12D inhibitor 20 相关抗体:
体内研究
(In Vivo)

KRAS G12D inhibitor 20 (6 mg/kg，腹腔注射，6 次注射) 对健康 BALB/c 雌性小鼠的体重没有显着变化[1]。
在使用携带 KRASG12D (PANC-1) 的免疫缺陷 SCID 雄性小鼠的异种移植小鼠模型中，KRAS G12D inhibitor 20 (6 mg/kg，腹腔注射) 可将肿瘤体积减少 13.1%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

342.44

Formula

C18H26N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12D inhibitor 20 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 20RasPANC-1BxPC3pancreatic cancerInhibitorinhibitorinhibit

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产品名称：
KRAS G12D inhibitor 20
目录号：
HY-162366
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