2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-20

KRAS inhibitor-20 是一种 KRasG12C 致癌突变体的小分子抑制剂。KRAS inhibitor-20 抑制 KRasG12C 的 IC50 <10 nM。

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KRAS inhibitor-20 Chemical Structure

KRAS inhibitor-20 Chemical Structure

CAS No. : 2411786-32-6

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KRAS inhibitor-20 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].

IC50 & Target[1]

KRAS(G12C)

<10 nM (IC50, [1])

体外研究
(In Vitro)

KRAS inhibitor-20 (compound 12b) results KRasG12C alkylation human lung cancer adenocarcinoma (HCC 1171) with an EC50 value of 3.3 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS inhibitor-20 相关抗体:
分子量

604.68

Formula

C31H40F4N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS inhibitor-20 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-202411786-32-6KRAS inhibitor20KRAS inhibitor 20Rasoncogenic mutantalkylationhuman lung cancer adenocarcinomaHCC 1171RAS proteinInhibitorinhibitorinhibit

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KRAS inhibitor-20
目录号：
HY-151287
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