2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C inhibitor 18

KRAS G12C inhibitor 18 是一种口服有效的 KRAS G12C 抑制剂。KRAS G12C inhibitor 18 具有抗肿瘤活。

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KRAS G12C inhibitor 18 Chemical Structure

KRAS G12C inhibitor 18 Chemical Structure

CAS No. : 2649788-45-2

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KRAS G12C inhibitor 18 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS G12C inhibitor 18 is a potent and orally active KRAS G12C inhibitor. Anti-tumor activities[1].

IC50 & Target[1]

KRas G12C

 

体外研究
(In Vitro)

KRAS G12C inhibitor 18 (compound 34) inhibits the growth of many KRas G12C mutant tumor cell lines (such as H358, SW1436, MiaPaca-2 cells, etc.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS G12C inhibitor 18 相关抗体:
体内研究
(In Vivo)

KRAS G12C inhibitor 18 exhibits a dose dependent inhibiton of pERK and active KRas after a single dose treatment from 12.5 to 100 mg/kg at 8 hours[1].
KRAS G12C inhibitor 18 (30 mg/kg; p.o.; twice daily) exhibits anti-tumor growth activity in lung cancer H358 xenograft mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

510.97

Formula

C25H20ClFN4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12C inhibitor 18 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C inhibitor 182649788-45-2RasH358SW1436MiaPaca-2cellsKRasG12CmutanttumorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-132979
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