2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. XRP44X

XRP44X 抑制 Ras 诱导的转录激活，IC50 为 10 nM。XRP44X 通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。。XRP44X 是 Elk3 抑制剂；XRP44X 还对微管有影响。

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XRP44X Chemical Structure

XRP44X Chemical Structure

CAS No. : 729605-21-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥352
In-stock
5 mg ￥320
In-stock
10 mg ￥500
In-stock
25 mg ￥1000
In-stock
50 mg ￥1600
In-stock
100 mg ￥2450
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

XRP44X 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XRP44X inhibits Ras-induced transcription activation with the IC50 of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2[1]. XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules[2].

IC50 & Target[1]

Ras

10 nM (IC50)

体外研究
(In Vitro)

XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC50 of∼10 nM[1].
XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1].
XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

XRP44X 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HUVEC, NIH3T3, HCT-116, and NIH3T3-Ki-Ras cells
Concentration: 10 nM
Incubation Time: 24, 48, 72, 96 hours
Result: Inhibited HUVEC, HCT 116,NIH3T3, and NIH3T3-RAS cells proliferation with IC50s of 2.2±0.5 nM, 2.3±0.5 nM, 4±0.5 nM, and 2.3±0.5 nM, respectively.
Inhibited the growth of immortalized mouse fibroblasts.

Western Blot Analysis[1]

Cell Line: HUVEC cells
Concentration: 100 nM
Incubation Time: Pretreated for 90 minutes
Result: Inhibited phosphorylation of Rsk-1.
Inhibited phosphorylation of Erk-1/2 on sites required for its activation without affecting overall levels of Erk-1/2.
体内研究
(In Vivo)

XRP44X may have therapeutic potential for refractory asthma[1].
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (BALB/c nu/nu)[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; treated daily for 6 days
Result: Inhibited cell tumor formation by xenografts in nude mice.
分子量

380.87

Formula

C21H21ClN4O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (131.28 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6256 mL 13.1278 mL 26.2557 mL
5 mM 0.5251 mL 2.6256 mL 5.2511 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

XRP44X 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6256 mL 13.1278 mL 26.2557 mL 65.6392 mL
5 mM 0.5251 mL 2.6256 mL 5.2511 mL 13.1278 mL
10 mM 0.2626 mL 1.3128 mL 2.6256 mL 6.5639 mL
15 mM 0.1750 mL 0.8752 mL 1.7504 mL 4.3759 mL
20 mM 0.1313 mL 0.6564 mL 1.3128 mL 3.2820 mL
25 mM 0.1050 mL 0.5251 mL 1.0502 mL 2.6256 mL
30 mM 0.0875 mL 0.4376 mL 0.8752 mL 2.1880 mL
40 mM 0.0656 mL 0.3282 mL 0.6564 mL 1.6410 mL
50 mM 0.0525 mL 0.2626 mL 0.5251 mL 1.3128 mL
60 mM 0.0438 mL 0.2188 mL 0.4376 mL 1.0940 mL
80 mM 0.0328 mL 0.1641 mL 0.3282 mL 0.8205 mL
100 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6564 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XRP44X729605-21-4RasRas-induced transcriptionRas-Erk-1/2 pathwayrefractory asthmaRas/Erk activationmicrotubulesInhibitorinhibitorinhibit

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目录号：
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