2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-14

KRAS inhibitor-14 (compound 3-22) 是一种有效的 KRAS G12C 抑制剂，IC50 为 0.249 µM。KRAS inhibitor-14 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC50s 分别为 1.12，>33.3 µM。KRAS inhibitor-14 具有研究胰腺癌，结直肠癌和肺癌的潜力。

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KRAS inhibitor-14 Chemical Structure

KRAS inhibitor-14 Chemical Structure

CAS No. : 2230873-78-4

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KRAS inhibitor-14 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

IC50 & Target[1]

KRas G12C

0.249 μM (IC50)

分子量

486.77

Formula

C20H15Cl3FN3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS inhibitor-14 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-142230873-78-4KRAS inhibitor14KRAS inhibitor 14RasMIA PaCA-2A549anticancerp-ERKpancreaticcolorectallung cancerInhibitorinhibitorinhibit

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