2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-37

KRAS inhibitor-37 (compound 2) 是一种有效的 KRAS 抑制剂，对 KRAS 野生型、KRAS G12D、KRAS G12C 和 KRAS G12V 的 KD 分别为 0.004 nM、0.041 nM、0.019 nM 和 0.144 nM。KRAS inhibitor-37 抑制细胞增殖，对 H358、SW620、PANC08.13 细胞的 IC50 分别为 <2 nM-14 nM。KRAS inhibitor-37 具有癌症研究的潜力。

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KRAS inhibitor-37 Chemical Structure

KRAS inhibitor-37 Chemical Structure

CAS No. : 3058573-95-5

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KRAS inhibitor-37 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS inhibitor-37 (compound 2) is a potent KRAS inhibitor with KDs of 0.004 nM, 0.041 nM, 0.019 nM and 0.144 nM for KRAS wild type, KRAS G12D, KRAS G12C and KRAS G12V by SPR binding assay, respectively. KRAS inhibitor-37 inhibits cell proliferation with IC50s of <2 nM-14 nM for H358, SW620, PANC08.13 cells, respectively. KRAS inhibitor-37 has the potential for cancer research[1].

IC50 & Target[1]

K-Ras WT

0.004 nM (Kd)

KRas G12D

0.041 nM (Kd)

KRas G12C

0.019 nM (Kd)

KRas G12V

0.144 nM (Kd)

分子量

618.10

Formula

C32H33ClFN7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS inhibitor-37 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-373058573-95-5KRAS inhibitor37KRAS inhibitor 37RasKRAS wild typeKRAS G12DKRAS G12CKRAS G12VH358SW620PANC08.13Inhibitorinhibitorinhibit

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