2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. ASP6918

ASP6918 是一种有效的口服活性 KRAS G12C 抑制剂，IC50 值为 0.028 µM。ASP6918 抑制细胞生长。ASP6918 显示出抗肿瘤活性。

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ASP6918 Chemical Structure

ASP6918 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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ASP6918 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity[1].

IC50 & Target[1]

KRas G12C

0.028 μM (IC50)

体外研究
(In Vitro)

ASP6918 (compound 29a) (6 days) 抑制 NCI-H1373 细胞的细胞生长，IC50 值为 0.0061 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ASP6918 相关抗体:

Cell Viability Assay[1]

Cell Line: NCI-H1373 cells
Concentration:
Incubation Time: 6 days
Result: Inhibited cell growth with an IC50 value of 0.0061 µM.
体内研究
(In Vivo)

ASP6918 (10, 20, 40, 60 mg/kg; p.o.; daily for 13 days) 在 NCI-H1373 异种移植小鼠模型中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old male nude mice (NCI-H1373 xenograft mouse model)[1]
Dosage: 10, 20, 40, 60 mg/kg
Administration: Oral, daily for 13 days
Result: Inhibited of tumor growth with tumor growth inhibition (TGI) rate of 27%, 68%, 49%, 73% at 10, 20, 40, 60 mg/kg.
分子量

621.77

Formula

C36H43N7O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ASP6918 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP6918ASP 6918ASP-6918RasNCI-H1373 cellsoral activityantitumorInhibitorinhibitorinhibit

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产品名称：
ASP6918
目录号：
HY-162249
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