2. GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. Ras Phosphatase
  4. DUSP6-IN-1

DUSP6-IN-1 (compound 24) 是靶向 DUSP6 的抑制剂，对 KRAS G12C, G12D, G12V 的 IC50 分别为 1.3 nM, 4.7 nM 和 0.3 nM; 对 KRAS G12V, WT KRAS, WT HRAS, WT NRAS-BRAF 与 CYPA 相互作用的 IC50 分别为 7 nM, 32 nM, 38 nM 和 35 nM; 对 KRAS-BRAF 和 CYPA 在 G12C, G12D, G12V 条件下的 IC50 分别为 9.7 nM, 49.5 nM 和 7.1 nM; 抑制 pERK 时，对 G12C 和 G12V 的 IC50 均小于 0.6 nM，对 G12D 的 IC50 为0.9 nM。

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DUSP6-IN-1 Chemical Structure

DUSP6-IN-1 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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DUSP6-IN-1 相关抗体

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DUSP6-IN-1 (compound 24) is an inhibitor targeting DUSP6, with IC50 values of 1.3 nM, 4.7 nM and 0.3 nM for KRAS G12C, G12D and G12V, respectively; IC50 values of 7 nM, 32 nM, 38 nM and 35 nM for the interaction of KRAS G12V, WT KRAS, WT HRAS and WT NRAS-BRAF with CYPA, respectively; IC50 values of 9.7 nM, 49.5 nM and 7.1 nM for KRAS-BRAF and CYPA under G12C, G12D and G12V, respectively; when inhibiting pERK, IC50 values for G12C and G12V are less than 0.6 nM, andIC50value for G12D is 0.9 nM[1].

IC50 & Target

KRas G12C

1.3 nM (IC50)

KRas G12D

4.7 nM (IC50)

KRas G12V

0.3 nM (IC50)

体外研究
(In Vitro)

DUSP6-IN-1 抑制 NCI-H23, NCI-H358, NCI-H2444, RKN, SW620 细胞增殖，IC50 为 0.17 nM，0.12 nM，0.17 nM，0.045 nM，0.1 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DUSP6-IN-1 相关抗体:
体内研究
(In Vivo)

DUSP6-IN-1 (30 mg/kg，口服，每日一次) 在脑肿瘤小鼠模型中抑制肿瘤生长，促进肿瘤消退[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSCLC MB mouse[1]
Dosage: 30 mg/kg
Administration: Oral gavage (p.o.); daily
Result: Made T/C 0.52% and TGI 104.68%.
分子量

837.08

Formula

C46H60N8O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DUSP6-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DUSP6-IN-1RasPhosphatasePan-RASMAPKG12CG12DG12VInhibitorinhibitorinhibit

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目录号：
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