2. MAPK/ERK Pathway GPCR/G Protein Stem Cell/Wnt Apoptosis
  3. Ras ERK Apoptosis
  4. K20

K20 是一种有效的选择性 KRas G12C 抑制剂，IC50 为 1.16 µM。K20 在 H358 细胞中显示出抗癌活性（IC50= 0.78 µM）。K20 降低 Erk 的磷酸化水平并导致癌细胞凋亡 (apoptosis)。K20 可抑制 NCI-H358 肿瘤细胞生长，TGI 为 41%，且未引起明显毒性。

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K20 Chemical Structure

K20 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

K20 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K20 is a potent and selective KRas G12C inhibitor with an IC50 of 1.16 µM. K20 shows anticancer activity in H358 cells (IC50= 0.78 µM). K20 decreases the levels of phosphorylated Erk and leads to cancer cell apoptosis. K20 suppresses NCI-H358 tumor growth with a TGI of 41% without causing obvious toxicity[1].

IC50 & Target

KRAS(G12C)

1.16 μM (IC50)

体外研究
(In Vitro)

K20 (24 h) shows selective cytotoxicity (5 to 23-fold) against KRas G12C mutated cells (H358, IC50=0.78 µM) over other KRas mutant (e.g.G12D, G12D, G12S, G12V) cancer cells (IC50s of 6.34, 17.74, 4.78, 5.03, 4.05 µM in HCT116 (G13D), A549 (G12S), Pancl (G12D), Hela (WT), SW620 (G12V), respectively)[1].
K20 (0, 0.5, 2 µM; 24 h) induces apoptosis of NCI-H358 cells[1].
K20 (0, 0.5, 1.0, 2.5, 5.0 µM; 48 h) decreases pErk (phosphorylated Erk) levels in NCI-H358 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K20 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: H358, H23, HCT116, A549, Pancl, Hela, SW620 cells
Concentration:
Incubation Time: 24 h
Result: Showed selective cytotoxicity (5 to 23-fold) against KRas G12C mutated cells (H358, IC50=0.78 µM) over other KRas mutant (e.g.G12D, G12D, G12S, G12V) cancer cells (IC50s of 6.34, 17.74, 4.78, 5.03, 4.05 µM in HCT116 (G13D), A549 (G12S), Pancl (G12D), Hela (WT), SW620 (G12V), respectively).

Apoptosis Analysis[1]

Cell Line: NCI-H358 cells
Concentration: 0, 0.5, 2 µM
Incubation Time: 24 h
Result: Induced apoptosis of NCI-H358 cells.

Western Blot Analysis[1]

Cell Line: NCI-H358 cells
Concentration: 0, 0.5, 1.0, 2.5, 5.0 µM
Incubation Time: 48 h
Result: Decreased pErk (phosphorylated Erk) levels in NCI-H358 cells.
体内研究
(In Vivo)

K20 (35 mg/kg; i.p.; every other day for 14 days) shows high tumor suppressive effects with a tumor growth inhibition (TGI) of 41% at 35 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male BALB/c nude mice ( xenograft model)[1]
Dosage: 35 mg/kg (dissolved in a 5%:35%:60% ratio of DMSO: castor oil: normal saline solution)
Administration: i.p.; every other day; 14 days
Result: Showed high tumor suppressive effects with a tumor growth inhibition (TGI) of 41% at 35 mg/kg.
分子量

543.34

Formula

C24H20Cl2F4N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K20K 20K-20RasERKApoptosisExtracellular signal regulated kinasesxenograft modelanticancerselectiveNCI-H358 cellsapoptosisInhibitorinhibitorinhibit

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