1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. LY314228

LY314228 是一种氨基胍 5-HT2 拮抗剂,对 5-HT2A 受体具有相对选择性 (IC50: 147.9 nM)。LY314228 靶向 5-HT 不同亚型的 Ki 值分别为 65 nM (5-HT 2A), 1214 nM (5-HT 2B), 168 nM (5-HT 2C)。LY314228 可有效抑制 5-HT 诱导的大鼠爪水肿,在切除卵巢的雌性大鼠中的 ED50 为 6.4 mg/kg。

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LY314228 Chemical Structure

LY314228 Chemical Structure

CAS No. : 182633-54-1

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  • 生物活性

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生物活性

LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values ??of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats.[1].

IC50 & Target

Ki: 65 nM (5-HT 2A), 1214 nM (5-HT 2B), 168 nM (5-HT 2C)[1]

分子量

368.43

Formula

C20H24N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LY314228
目录号:
HY-117792
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