2. Academic Validation
  3. Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

Anti-allergic prenylated flavonoids from the roots of Sophora flavescens

  • Planta Med. 2008 Feb;74(2):168-70. doi: 10.1055/s-2008-1034285.
Wenying Quan 1,  Hee Ju Lee,  Chul Young Kim,  Chu Won Noh,  Byung Hun Um,  Min-Ho Oak,  Kyeong-Man Kim
Affiliations

Affiliation

  • 1 Department of Pharmacology, Drug Development Research Center, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
PMID: 18219599 DOI: 10.1055/s-2008-1034285
Abstract

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated Flavonoids ( 1 - 8) responsible for the IN VITRO anti-allergic activity. Among them, kushenol N ( 3), sophoraflavanone G ( 6), and leachianone A ( 7) demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells with IC (50) values ranging from 15 to 30 muM.

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