2. Academic Validation
  3. The Immunobiology of the Interleukin-12 Family: Room for Discovery

The Immunobiology of the Interleukin-12 Family: Room for Discovery

  • Immunity. 2019 Apr 16;50(4):851-870. doi: 10.1016/j.immuni.2019.03.011.
Elia D Tait Wojno 1,  Christopher A Hunter 2,  Jason S Stumhofer 3
Affiliations

Affiliations

  • 1 Baker Institute for Animal Health and Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, 235 Hungerford Hill Rd., Ithaca, NY 14853, USA.
  • 2 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Ave., Philadelphia, PA 19104-4539, USA. Electronic address: chunter@vet.upenn.edu.
  • 3 Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 West Markham St., Little Rock, AR 72205, USA. Electronic address: jstumhofer@uams.edu.
PMID: 30995503 DOI: 10.1016/j.immuni.2019.03.011
Abstract

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of Cancer, Infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Here, we review the landmark discoveries in this field, the combinatorial biology inherent to this family, and how patient datasets have underscored the critical role of these pathways in human disease. We present significant knowledge gaps, including how similar signals from these cytokines can mediate distinct outcomes, and discuss how a better understanding of the biology of the IL-12 family provides new therapeutic opportunities.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z