2. Academic Validation
  3. Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A

Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A

  • Acta Biochim Pol. 2020 Jun 18;67(2):219-223. doi: 10.18388/abp.2020_5201.
Lalu Rudyat Telly Savalas 1,  Baiq Repika Nurul Furqon 2,  Dina Asnawati 2,  Jannatin 'Ardhuha 3,  Prapti Sedijani 1,  Saprizal Hadisaputra 4,  Baiq Nila Sari Ningsih 5,  Jufrizal Syahri 6
Affiliations

Affiliations

  • 1 Department of Biology Education, Faculty of Teacher Training and Education, University of Mataram.
  • 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram.
  • 3 Department of Physics Education, Faculty of Teacher Training and Education, University of Mataram.
  • 4 Department of Chemistry Education, Faculty of Teacher Training and Education, University of Mataram.
  • 5 Department of Chemistry, Faculty of Science, Prince of Songkhla University, Thailand.
  • 6 Department of Chemistry, Universitas Muhammadiyah Riau, Indonesia.
PMID: 32559055 DOI: 10.18388/abp.2020_5201
Abstract

Small protein tyrosine Phosphatase (PtpA) of Mycobacterium tuberculosis is attributed to the development of latent tuberculosis Infection, and hence bocomes an interesting target for drug development. In this communication, inhibition of PtpA by naturally occurring fatty acids cis-2 and trans-2-eicosenoic acid is investigated. Mtb PtpA was heterologously expressed in Escherichia coli, and the activity of PtpA was inhibited by cis-2 and trans-2 eicosenoic fatty acids. Both compunds showed strong inhibition of PtpA activity with IC50 at low micromolar concentration. As comparison, trans-11-eicosenoic acid only slightly inhibit PtpA. In silico analysis confirmed the inhibition of PtpB by cis-2-eicosenoic acid by formation of several hydrogen bonds. These findings show that cis-2 and trans-2 eicosenoic fatty acids are potential candidates for latent tuberculosis inhibitors.

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