1. Academic Validation
  2. OX40 agonists for cancer treatment: a patent review

OX40 agonists for cancer treatment: a patent review

  • Expert Opin Ther Pat. 2021 Jan;31(1):81-90. doi: 10.1080/13543776.2021.1825688.
Jorge Cebada 1 Martin Perez-Santos 2 Cindy Bandala 3 4 Eleazar Lara-Padilla 4 Irma Herrera-Camacho 5 Nora Hilda Rosas-Murrieta 6 Lourdes Millán-Pérez Peña 6 Eduardo Monjaraz 7 Amira Flores 8 Maricruz Anaya-Ruiz 8
Affiliations

Affiliations

  • 1 Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2706, Col. Volcanes, CP 72410 Puebla, Puebla, Mexico.
  • 2 Dirección de Innovación y Transferencia de Conocimiento, Benemérita Universidad Autónoma de Puebla, Puebla CP 72570, México.
  • 3 Departamento de Neurociencias, Instituto Nacional de Rehabilitación, Ciudad de México, Mexico.
  • 4 Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
  • 5 Laboratorio de Bioquímica y Biología Molecular, Centro de Química del Instituto de Ciencias (ICUAP), Edificio 103F, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, CP 72592 Puebla, Puebla, México.
  • 6 Laboratorio de Bioquímica y Biología Molecular, Centro de Química del Instituto de Ciencias (ICUAP), Edificio 103F, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, 72592 Puebla, Puebla, México.
  • 7 Instituto de Fisiología, Benemerita Universidad Autónoma de Puebla, Av. 14 Sur 6301 Colonia Jardines de San Manuel CP 72570 Puebla, Puebla, Mexico.
  • 8 Laboratorio de Biología Celular, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla CP 74360, México.
Abstract

Introduction: OX40 is an immune checkpoint in Cancer and its presence in Cancer is a good prognosis, making it a highly relevant target for the development of new immunotherapies.

Areas covered: The patent literature reveals vital information on new trends in Cancer therapies. The authors used the patent databases of the six major patent offices in the world: United States Patent and Trademark Office, European Patent Office, World Intellectual Property Organization, Japan Patent Office, State Office of Intellectual Property of China and Korean Intellectual Property Office, to generate a panorama of patents related to OX40 agonists. Specific patents have been grouped into innovative patents and adoption patents.

Expert opinion: An increasing trend in the development of OX40 agonists in Cancer, particularly in the years 2018 and 2019. United States was the leader in generating patents, followed by China and England. Major pharmaceutical companies have at least one anti-OX40 agonist, MEDI6469 and MEDI-0562 (AstraZeneca), PF-04518600 (Pfizer), GSK3174998 (GlaxoSmithKline), BMS-986,178 (Bristol-Myers Squibb) and MOXR0916 (Roche), which represent 68% of clinical trials conducted with OX40 agonists.

Keywords

OX40; cancer; immunotherapy; patent.

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