2. Academic Validation
  3. Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle

Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle

  • Acta Biomater. 2020 Dec:118:196-206. doi: 10.1016/j.actbio.2020.10.009.
Di Huang 1,  Feng Yue 2,  Jiamin Qiu 3,  Meng Deng 4,  Shihuan Kuang 5
Affiliations

Affiliations

  • 1 Department of Animal Sciences, Purdue University, West Lafayette, IN, USA; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA; Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
  • 2 Department of Animal Sciences, Purdue University, West Lafayette, IN, USA. Electronic address: fyue@purdue.edu.
  • 3 Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.
  • 4 Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA; Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA; School of Materials Engineering, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
  • 5 Department of Animal Sciences, Purdue University, West Lafayette, IN, USA; Center for Cancer Research, Purdue University, West Lafayette, IN, USA. Electronic address: skuang@purdue.edu.
PMID: 33053428 DOI: 10.1016/j.actbio.2020.10.009
Abstract

Phosphatase and tensin homolog (PTEN) antagonizes muscle growth and repair, and inhibition of PTEN has been shown to improve the pathophysiology and dystrophic muscle function in a mouse model of Duchenne muscular dystrophy (DMD). However, conventional pharmacological delivery of PTEN inhibitors carries a high risk of off-target side effects in other non-muscle organs due to broad targeting spectrums. Here we report a muscle-targeted nanoparticulate platform for cell-specific delivery of a PTEN Inhibitor. Poly(lactide-co-glycolide)-b-poly(ethylene glycol) nanoparticles (NPs) are functionalized with a muscle-homing peptide M12 to promote the selective uptake by muscle cells/tissue in vitro and in vivo. Moreover, the NPs are formulated to slowly release the PTEN Inhibitor, preventing cytotoxicity associated with direct exposure to the drug and facilitating sustained inhibition of PTEN. This advanced delivery approach taking advantages of polymeric nanomaterials and muscle-homing Peptides opens a new avenue for the development of long-term therapeutic strategies in DMD treatment.

Keywords

Duchenne muscular dystrophy; Muscle-homing peptides; PTEN signaling; Polymeric nanoparticles; Targeted drug delivery.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z