2. Academic Validation
  3. Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway

Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway

  • Biochem Biophys Res Commun. 2023 Apr 26;663:192-201. doi: 10.1016/j.bbrc.2023.04.072.
Zheng Peng 1,  Xiao-Jian Li 1,  Cong Pang 2,  Jia-Tong Zhang 1,  Qi Zhu 3,  Jia-Qing Sun 4,  Juan Wang 1,  Bo-Qiang Cao 1,  Yu-Hua Zhang 1,  Yue Lu 1,  Wei Li 1,  Chun-Hua Hang 5,  Zong Zhuang 6
Affiliations

Affiliations

  • 1 Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China.
  • 2 Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China; Department of Neurosurgery, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
  • 3 Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, Jiangsu, China.
  • 4 Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Xuzhou, China.
  • 5 Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China. Electronic address: hang_neurosurgery@163.com.
  • 6 Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, China. Electronic address: zhuangzong@njglyy.com.
PMID: 37141668 DOI: 10.1016/j.bbrc.2023.04.072
Abstract

The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. In a clinical trial of inhaled hydrogen in patients with subarachnoid hemorrhage (SAH), we found that hydrogen reduced the accumulation of lactic acid in the nervous system. There are no studies demonstrating the regulatory effect of hydrogen on lactate and in this study we hope to further clarify the mechanism by which hydrogen regulates lactate metabolism. In cell experiments, PCR and Western Blot showed that HIF-1α was the target related to lactic acid metabolism that changed the most before and after hydrogen intervention. HIF-1α levels were suppressed by hydrogen intervention treatment. Activation of HIF-1α inhibited the lactic acid-lowering effect of hydrogen. We have also demonstrated the lactic acid-lowering effect of hydrogen in animal studies. Our work clarifies that hydrogen can regulate lactate metabolism via the HIF-1αpathway, providing new insights into the neuroprotective mechanisms of hydrogen.

Keywords

HIF-1α; Hydrogen; Lactic acid; Subarachnoid hemorrhage.

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