2. Anti-infection Immunology/Inflammation GPCR/G Protein Neuronal Signaling
  3. Antibiotic Bacterial Histamine Receptor
  4. Methdilazine

Methdilazine  (Synonyms: 甲地嗪)

目录号: HY-B1690
产品使用指南

摩尔计算器

Methdilazine 是一种具有口服活性的抗生素 (组胺拮抗剂)。Methdilazine hydrochloride 在体外和体内水平均能抑制多种分枝杆菌的活性，其 MIC 值为 5-15 μg /mL，可用于传染病相关的研究。

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Methdilazine Chemical Structure

Methdilazine Chemical Structure

CAS No. : 1982-37-2

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Methdilazine 的其他形式现货产品:

Customer Review

Other Forms of Methdilazine:

Methdilazine 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2].

IC50 & Target

MIC: 5-15 μg/mL (mycobacterium)
体外研究
(In Vitro)

Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methdilazine 相关抗体:

Cell Proliferation Assay[1]

Cell Line: mycobacterium: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus.
Concentration: 0-20 μg/mL approximately
Incubation Time: 18 h
Result: Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
体内研究
(In Vivo)

Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice[1].
Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H37Rv infected mice[1]
Dosage: 10 μg/gm body wt/day, 6 weeks
Administration: Intraperitoneal injection
Result: Displayed an anti-mycobacterial activity to mycobacteria.
Animal Model: Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2]
Dosage: 10 mg/kg per day for 28 days
Administration: Oral administration
Result: Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
分子量

296.43

Formula

C18H20N2S
CAS 号
中文名称

甲地嗪
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methdilazine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methdilazine1982-37-2甲地嗪AntibioticBacterialHistamine ReceptorMycobacteriosisMycobacterium Tuberculosis (Mtb)cholinergic antagonistH37Rv infected mice.Inhibitorinhibitorinhibit

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