2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Methylergometrine

Methylergometrine  (Synonyms: Methylergonovine; Ryegonovin free base; Spametrin F free base)

目录号: HY-153027
产品使用指南

摩尔计算器

Methylergometrine (Methylergonovine) 是一种具有口服活性的 5-HT2B 配体激动剂。Methylergometrine 的分布半衰期仅为 1-2 分钟。Methylergometrine 可作为催产药物，用于治疗子宫松弛。

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Methylergometrine Chemical Structure

Methylergometrine Chemical Structure

CAS No. : 113-42-8

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Methylergometrine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methylergometrine (Methylergonovine) is an orally active 5-HT2B ligand agonist. The distribution half-life of Methylergometrine is only 1-2 min. Methylergometrine can be used as an oxytocin to treat uterine atony[1][2][3].

IC50 & Target[1]

5-HT2B Receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 250 μM
Compound: methyl ergonovine
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
[PMID: 23241029]
体内研究
(In Vivo)

Methylergometrine (0.2 mg/kg；静脉注射；单剂量) 出现在家兔子宫、肝脏和肾脏中，平均浓度分别为 34 ng/g、80 ng/g 和 203 ng/g (给药 30 min 后)[3]。
Methylergometrine 在家兔中的药代动力学 (PK) 参数[3]

CO ng/mL K12/min K21/min Ke1/min
mean 755.3 0.577 0.180 0.140
S.D. 215.8 0.098 0.036 0.069
T1/2α/min T1/2β/min Vdc L/kg Vdss L/kg Vdβ L/kg AUCtot (ng/mL)•min CLtot mL/min
mean 0.91 26.34 0.29 1.13 1.44 6060.88 83.74
S.D. 0.35 9.48 0.09 0.30 0.55 2005.30 17.86

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

339.43

Formula

C20H25N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methylergometrine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylergometrine113-42-8MethylergonovineRyegonovinSpametrin F5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorRabbitsUterusLiverKidneysInhibitorinhibitorinhibit

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