2. PI3K/Akt/mTOR
  3. PI3K
  4. MIPS-9922

MIPS-9922 是一种强效且选择性的 PI3Kβ 抑制剂，IC50 为 63 nM。MIPS-9922 抑制 PI3Kβ 的效力比 PI3Kδ 高 30 倍以上。MIPS-9922 阻断 PI3K 介导的血小板糖蛋白 αIIbβ3 活化和血小板粘附。MIPS-9922 具有抗血小板和抗血栓活性。

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MIPS-9922 Chemical Structure

MIPS-9922 Chemical Structure

CAS No. : 1416956-33-6

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MIPS-9922 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities[1].

IC50 & Target[1]

PI3Kβ

63 nM (IC50)

PI3Kδ

2200 nM (IC50)

体外研究
(In Vitro)

MIPS-9922 可有效抑制 ADP 诱导的洗涤性血小板聚集。MIPS-9922 还可抑制整合素 αIIbβ3 活化和 αIIbβ3 依赖性血小板在高剪切下粘附于固定的血管性血友病因子 (vWF)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MIPS-9922 相关抗体:
体内研究
(In Vivo)

MIPS-9922 (2.5 mg/kg，颈静脉推注；一次) 可防止体内电解血栓小鼠模型中动脉血栓形成，而不会引起长时间出血或过度失血[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice bearing electrolytic injury[1]
Dosage: 2.5 mg/kg
Administration: Bolus jugular vein injection; once
Result: Prevented arterial thrombus formation in the in vivo electrolytic mouse model of thrombosis.
分子量

563.60

Formula

C28H31F2N9O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MIPS-9922 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIPS-99221416956-33-6MIPS9922MIPS 9922PI3KPhosphoinositide 3-kinaseAnti-platelet activityplatelet aggregationAnti-thrombotic activityPI3Kβ inhibitorInhibitorinhibitorinhibit

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目录号：
HY-120265
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